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OBJECTIVES A birth cohort was followed-up to age 4 years to record the development of allergic disorders and to study the influence of genetic and environmental factors. METHODS Information on family history and environmental factors was obtained at birth, and serum cord IgE was measured. At age 4 years, 1218 children were reviewed. RESULTS By age 4(More)
Coeliac disease (gluten enteropathy) and cystic fibrosis are both diagnosed fairly often in paediatric practice. The incidence of coeliac disease in London was estimated in 1959 as 1 in 3000 (Carter, Sheldon, and Walker, 1959), but this is almost certainly an underestimate, for the data were collected before the routine use of jejunal biopsy enabled the(More)
There is much evidence that the development of allergic disorders may be related to early exposure of allergens, including those in breastmilk. We have tried to find out whether avoidance of food and inhaled allergens in infancy protects against the development of allergic disorders in high-risk infants. In a prenatally randomised, controlled study 120(More)
The effect of genetic and environmental factors on the prevalence of allergic disorders in early childhood was determined in a prospective follow-up study. Information was available on 1174 children at the age of 2 years. Two-hundred and seventy-five were considered to have an allergic disorder. The prevalence varied from 3.2% for rhinitis to 10.9% for(More)
In an attempt to prevent or reduce the manifestations of atopic disease, a group of infants considered to be genetically at high risk of atopy was entered in a prenatally randomized, controlled study. A prophylactic group (n = 58) was either breast-fed with their mothers excluding foods regarded as highly antigenic from their diets, or given an extensively(More)
A total of 1167 infants were followed for 1 year in a population-based prospective study to assess the effect of environmental factors on the development of allergic disorders. Some of these environmental factors are interdependent. Mothers who formula fed their infants smoked more often (p less than 0.001) and tended to belong to lower social classes (p(More)
OBJECTIVE To determine the prevalence of sensitisation to peanuts and tree nuts in all children born during one year in one geographical area. DESIGN Birth cohort study with structured review at ages 1, 2, and 4 years. SETTING All children born on the Isle of Wight between January 1989 and February 1990. SUBJECTS Of 1456 children originally included,(More)
BACKGROUND One hundred twenty children, identified before birth as being at high risk for atopy, were prenatally assigned to prophylactic or control groups. METHODS The infants in the prophylactic group either received breast milk from mothers on an exclusion diet or an extensively hydrolyzed formula. Their bedrooms and living rooms were treated(More)