David Herron

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INTRODUCTION KRAS and EGFR ectodomain-acquired mutations in patients with metastatic colorectal cancer (mCRC) have been correlated with acquired resistance to anti-EGFR monoclonal antibodies (mAbs). We investigated the frequency, co-occurrence, and distribution of acquired KRAS and EGFR mutations in patients with mCRC refractory to anti-EGFR mAbs using(More)
The rates of appearance and removal of 7-methylguanine and O6-methylguanine in DNA from rat liver, kidney, and colon were determined at various intervals up to 120 hr after i.p. administration of 10.2, 40.7, 81.5, or 163 mg 1,2-dimethylhydrazine (SDMH) per kg body weight (one-sixteenth, one-fourth, one-half, or one 50% lethal dose) using high-pressure(More)
A system has been developed for stimulation, recording and analysis of a wide range of eye movements. Eye movements are stimulated with an LED bar or a video projector under the control of a PC. The eye movements are measured using a scleral reflection technique (IRIS instrument), and sampled and stored on a PC. A range of tests have been developed to(More)
DNA, isolated from two samples of human liver obtained from a suspected dimethylnitrosamine poisoning, contained 1363 to 1373 micromol of 7-methylguanine per mol of guanine and 273 to 317 micromol of O6-methylguanine per mol of guanine. Liver and kidney DNA obtained from unrelated cases contained no detectable methylated purines. From the DNA methylation(More)
PURPOSE This study tests the conventional wisdom that using fluoroscopy under identical geometrical conditions results in less radiation when using the mini C-arm relative to the large C-arm. METHODS We evaluated the radiation dose for both direct exposure and scatter 2.54 cm outside the intensifier. We used 3 mini and 3 large C-arms in a vertical(More)
The formation and persistence of O6-methylguanine and 7-methylguanine in colon, kidney, and liver DNA were measured over a period of 25 weeks during 1,2-dimethylhydrazine (SDMH) carcinogenesis. Rats were given 14 weekly s.c. injections of 21 mg SDMH/kg body wt., and methylated guanines in DNA were determined quantitatively one week after each injection to(More)
In order to examine the control of expression of the gene coding for the brown fat specific uncoupling protein thermogenin (UCP), brown fat cells isolated as undifferentiated precursors from the interscapular brown adipose tissue of young mice were grown in culture. In these cells, it was possible by norepinephrine (NE) addition to induce specifically the(More)
In 1974 the Connecticut statute on competence to stand trial was revised to allow the court the option of having competence evaluated by a clinical team consisting ofa psychiatrist, a psychologist, and a psychiatric social worker, rather than by a psychiatrist alone. l This article traces the history of the Connecticut statute on competence to stand trial(More)
This article identifies the major features of software cost estimation tools and how they are being used together technically with project management tools. This article describes a number of experiences of early estimation of software reliability for large real-time telecommunications systems. Estimating Web Development Costs: There Are Differences The(More)
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