David Haughton

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In recent times, the application of deoxyribonucleic acid (DNA) has diversified with the emergence of fields such as DNA computing and DNA data embedding. DNA data embedding, also known as DNA watermarking or DNA steganography, aims to develop robust algorithms for encoding non-genetic information in DNA. Inherently DNA is a digital medium whereby the(More)
OBJECTIVE To investigate the extent to which the detection of antibodies to gliadin, endomysium, and jejunum predicts the eventual diagnosis of coeliac disease according to the revised ESPGAN diagnostic criteria in a group of patients in whom there is a high suspicion of coeliac disease. DESIGN Clinical assessment and laboratory analysis of patients with(More)
The binding of vinblastine (VLB) to recrystallized human alpha 1-acid glycoprotein (alpha 1-AGP) dissolved in phosphate-buffered saline (pH 7.4) was determined at different drug concentrations using the technique of continuous ultrafiltration. Vinblastine was extremely highly bound (greater than 99.0%) at a drug concentration of 4.0 mumol X l-1, dropping to(More)
BACKGROUND The application of flow cytometric assays, for determination of phagocyte respiratory burst (ROB) activity, to the investigation of chronic granulomatous disease (CGD) may lead to improved laboratory detection of patients and carriers and indicate the nature of the molecular defect. To evaluate the diagnostic capability of flow cytometry an(More)
DNA data embedding is a newly emerging field aspiring to encode data in deoxyribonucleic acid (DNA). DNA is an inherently digital and noisy medium, undergoing substitution, insertion and deletion mutations. Hence, encoding information in DNA can be seen as a particular case of digital communications in which biological constraints must be observed. In this(More)
We show that Slepian's Variant I permutation codes implement firstorder perfect steganography (i.e., histogram-preserving steganography). We give theoretical expressions for the embedding distortion, embedding rate and embedding efficiency of permutation codes in steganography, which demonstrate that these codes conform to prior analyses of the properties(More)
Biomarkers for Alzheimer's disease (AD) should meet several criteria, including simplicity of testing. Inappropriate activation of the complement cascade has been implicated in the pathogenesis of AD. Complement factor H (CFH) is a regulator of the cascade, but studies on plasma CFH levels in AD have provided mixed results. This study compared plasma CFH(More)
Slepian's variant I permutation coding has been recently shown to be a fundamental steganographic tool, as it implements optimum perfect steganography of memoryless sources. Although real host signals are not memoryless, a decorrelating energy-preserving transform can always be applied before a method that assumes a memoryless source, as is usually done in(More)