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OBJECTIVE To investigate the role of serine-threonine phosphorylation on the activity of human P450c17. DESIGN In vitro study. SETTING Academic basic research laboratory. PATIENT(S) None. (More)
OBJECTIVE Insulin resistance is a common feature of polycystic ovary syndrome (PCOS). The insulin signaling pathway consists of two major pathways, the metabolic and the mitogenic cascades. The many(More)
BACKGROUND We and others have observed that young girls predisposed to polycystic ovary syndrome (PCOS) display defective insulin sensitivity, beta-cell function and non-esterified fatty acids (NEFA)(More)
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