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1. The effect of adverse osmotic pressure gradients on fluid transfer and electrical potential across the wall of sacs of rat everted small intestine was investigated.2. Addition of mannitol to the mucosal fluid produced a potential change of 0.062 mV/m-osM and a decrease in fluid transfer of 0.015 ml./m-osM/hr. This is consistent with the production of(More)
1. A study was made of the transfer of L-alanine, D-alanine and beta-alanine by sacs of everted small intestine of the rat.2. D-Alanine and beta-alanine are transported against a concentration gradient and in this respect resemble L-alanine.3. Transfer of all three isomers was stimulated in presence of glucose, but stimulation was much greater with(More)