David H. Skuse

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BACKGROUND Women with Turner syndrome (TS; 45,X) lack a normal second X chromosome, and many are prescribed exogenous sex and growth hormones (GH). Hence, they allow us an opportunity to investigate genetic and endocrine influences on brain development. METHODS We examined brain anatomy and metabolism in 27 adult monosomic TS women and 21 control subjects(More)
Diffusion tensor imaging (DTI) studies have demonstrated white matter (WM) abnormalities in tracts involved in emotion processing in autism spectrum disorder (ASD), but little is known regarding the nature and distribution of WM anomalies in relation to ASD trait severity in adults. Increasing evidence suggests that ASD occurs at the extreme of a(More)
Turner syndrome (TS) is a model for X chromosome influences on neurodevelopment because it is most commonly caused by absence of one X chromosome and associated with altered brain structure and function. However, all prior in vivo magnetic resonance imaging studies of the brain in TS have either used manual approaches or voxel-based morphometry (VBM) to(More)
a Department of Child Psychiatry, Institute of Psychiatry, King's College London, London, UK b Child Psychiatry Branch, National Institutes of Mental Health, Bethesda, USA c Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK d Department of Endocrinology, Middlesex Hospital, London, UK e Behavioural Sciences(More)
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