David H. Kitson

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This report focuses on the results of SEI software process assessments conducted over a four-year period beginning in 1987. It characterizes the software processes used by software managers and practitioners at the assessed sites and classifies issues identified during the assessments. The basis for the characterization and classification is a software(More)
This report characterizes the software processes currently used by software managers and practitioners in the U.S. and Japan. The U.S. data for this comparative study of the state of software practice in the U.S. and Japan is drawn from extensive SEI assessments conducted from 1987 through 1989. The Japanese maturity data was gathered during a three-week(More)
Fourteen patients with angina pectoris completed a double blind trial of atenolol 25 mg, 50 mg, and 100 mg twice daily and propranolol 80 mg thrice daily. In comparison with placebo, all active treatments significantly reduced anginal attacks, consumption of glyceryl trinitrate, resting and exercise heart rate, resting and exercise systolic blood pressure,(More)
To maximise the assignment of function of the proteins encoded by a genome and to aid the search for novel drug targets, there is an emerging need for sensitive methods of predicting protein function on a genome-wide basis. GeneAtlas is an automated, high-throughput pipeline for the prediction of protein structure and function using sequence similarity(More)
A large-scale molecular dynamics simulation of the behavior of a serine protease (Streptomyces griseus protease A) in a crystalline environment has been performed. All atoms (including hydrogens) of two protein molecules and the surrounding solvent of crystallization, consisting of both water and salt ions, were explicitly represented, and a relatively long(More)
This is the first in a series of SEI reports to provide periodic updates on the state of software engineering practice in the DoD software community. The SEI has developed, and is refining, a process framework and assessment methodology for characterizing the processes used by software organizations to develop and evolve software products. This report(More)
Energy minimizations and molecular dynamics simulations have been performed on the cyclic peptide cyclo-(Ala-Pro-D-Phe)2 in both the isolated and crystal states. The results of these calculations have been analyzed, both to investigate our ability to reproduce experimental data (structure and vibrational and NMR spectra) and to investigate the effects of(More)
OBJECTIVES Cardiac arrest is associated with morbidity and mortality because of cerebral ischemia. Therefore, we tested the hypothesis that higher regional cerebral oxygenation during resuscitation is associated with improved return of spontaneous circulation, survival, and neurologic outcomes at hospital discharge. We further examined the validity of(More)
This paper focuses on the results of SEI software process assessments conducted over a four-year period beginning in 1987. It contributes to the existing body of knowledge on the state of practice of software engineering in the United States by characterizing software sites from a process matun”~ perspective and profiling st”te software process weaknesses.(More)
We have applied local density functional theory, an ab initio quantum mechanical method, to study the shift in the spatial electron density of the substrate dihydrofolate that accompanies binding to the enzyme dihydrofolate reductase. The results shed light on fundamental electronic effects due to the enzyme that may contribute to catalysis. In particular,(More)