Learn More
The basis of a three-dimensional (3D) ultrasound imaging system was constructed from a commercially available magnetometer-based position and orientation measurement (POM) device, a standard B-Mode ultrasound instrument and a personal computer. To evaluate the system's performance, a novel method was devised using an iterative, least-squares technique to(More)
OBJECTIVE To determine if metabolomic profiling of embryo culture media correlates with reproductive potential of individual embryos. DESIGN Prospective study. SETTING An academic and a private assisted reproduction program; a university research center. PATIENT(S) Women undergoing assisted reproduction treatment. INTERVENTION(S) Sixty-nine spent(More)
Multiwavelength optical spectroscopy was used to determine the oxygen-binding characteristics for equine myoglobin. Oxygen-binding relationships as a function of oxygen tension were determined for temperatures of 10, 25, 35, 37, and 40 degrees C, at pH 7.0. In addition, dissociation curves were determined at 37 degrees C for pH 6.5, 7.0, and 7.5.(More)
BACKGROUND The morphology of an embryo has a limited predictive value for assessing viability and ongoing pregnancy, therefore new selection tools are needed to maintain success rates with single-embryo transfer (SET). In this study, we investigated if metabolomic profiling of biomarkers of embryo culture medium by near-infrared (NIR) spectroscopy has a(More)
OBJECTIVE To determine if metabolomic profiling of embryonic development was associated with implantation rates in IVF. DESIGN Prospective blinded. SETTING University-affiliated assisted reproductive technology program. PATIENT(S) Unselected assisted reproductive technology population. INTERVENTION(S) None. MAIN OUTCOME MEASURE(S) Raman-based(More)
An imaging technique called orthogonal-plane fluorescence optical sectioning (OPFOS) was developed to image the internal architecture of the cochlea. Expressions for the three-dimensional point spread function and the axial and lateral resolution are derived. Methodologies for tissue preparation and for construction, alignment, calibration and(More)
OBJECTIVE To identify biomarkers associated with reproductive outcome using proton nuclear magnetic resonance ((1)H NMR) metabolomic profiling of embryo culture media. DESIGN Retrospective study. SETTING An academic assisted reproductive technology (ART) program; a university research center. PATIENT(S) Women undergoing ART treatment. (More)
A capillary electrophoresis method was used to measure albumin, immunoglobulin G (IgG), transferrin, and uric acid in 230 amniotic fluid (AF) samples collected at 15.15+/-0.06 weeks gestation. Species were quantified by external calibration using thiamine as internal standard. All major components were detected within 10 min. Migration time reproducibility(More)
OBJECTIVE To establish whether second trimester amniotic fluid protein and/or uric acid concentrations were associated with and predictive of infant birth weight and/or gestational age. METHODS Second trimester amniotic fluid samples (n = 230) in mothers undergoing age-related amniocentesis for genetic testing were collected and quantified using capillary(More)
BACKGROUND AND PURPOSE Studies have suggested that B-mode ultrasonography can be used to determine carotid plaque composition and that specific plaque characteristics are associated with a worse clinical outcome. However, histological studies examining the relationship between carotid plaque morphology and clinical outcome have reported conflicting(More)