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BACKGROUND Respiratory disease in patients with cystic fibrosis is characterized by airway obstruction caused by the accumulation of thick, purulent secretions, which results in recurrent, symptomatic exacerbations. The viscoelasticity of the secretions can be reduced in vitro by recombinant human deoxyribonuclease I (rhDNase), a bioengineered copy of the(More)
Chronic pulmonary infection is the major cause of morbidity and mortality in cystic fibrosis. High levels of DNA in the sputum make the sputum viscous and difficult to expectorate. Recombinant human deoxyribonuclease (rhDNase) in vitro has been shown to reduce the viscoelasticity of the sputum from CF patients. We have done a phase II double-blind(More)
We tested the hypothesis that recombinant human deoxyribonuclease 1 (rhDNase) reduces airflow obstruction and improves mucociliary clearance in patients with cystic fibrosis (CF), and that improvements seen in FEV1 and FVC after rhDNase treatment are independent of chest physical therapy (CPT). CF patients inhaled placebo (10 patients) or 2.5 mg rhDNAse(More)
OBJECTIVE Repeated end-range spinal movements producing specific pain responses (i.e. centralization or non-centralization) may be used for diagnostic and prognostic purposes. However, possible associations between psychological factors and pain responses have been reported. The aim of this study was to investigate the associations between pain responses in(More)
STUDY DESIGN Randomized clinical trial comparing two interventions in employees sick-listed 3 to 16 weeks because of low back pain (LBP). OBJECTIVE To compare 1-year return to work (RTW), pain, disability and physical and mental health dimensions in subjects offered a hospital-based multidisciplinary intervention or a brief intervention. SUMMARY OF(More)
OBJECTIVES To determine the effect of repeated doses of aerosolized recombinant human deoxyribonuclease (rhDNase) on the development of anti-rhDNase antibodies, acute allergic reactions, and pulmonary function in patients with cystic fibrosis. DESIGN A multicenter, open-label study in which 184 patients received 10 mg aerosolized rhDNase twice a day for(More)
STUDY DESIGN Prospective cohort study nested in a randomized clinical trial. OBJECTIVE To investigate the prognostic value of pain response classification at initial physiotherapy examination in patients with low back pain (LBP) who are sick-listed. BACKGROUND Recurrent and chronic LBP accounts for a substantial proportion of all absence from work. In(More)
BACKGROUND Multidisciplinary intervention is recommended for rehabilitation of employees sick-listed for 4-12 weeks due to low back pain (LBP). However, comparison of a brief and a multidisciplinary intervention in a randomised comparative trial of sick-listed employees showed similar return to work (RTW) rates in the two groups. The aim of the present(More)
INTRODUCTION The Constant Score (CS), developed as a scoring system to evaluate overall functionality of patients with shoulder disorders, is widely used but has been criticised for relying on an imprecise terminology and for lack of a standardised methodology. A modified guideline was therefore published in 2008 with several new recommendations, but a(More)
OBJECTIVE To cross-culturally adapt the Danish version of the Shoulder Pain and Disability Index and to evaluate its measurement properties in terms of reliability and known-group validity. DESIGN Test-retest study. SETTING Outpatient Clinic of the Department of Orthopaedic Surgery, Regional Hospital Herning, Denmark. SUBJECTS Consecutive shoulder(More)