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Strongtalk: Typechecking Smalltalk in a Production Environment

• Gilad Bracha, David Griswold
• OOPSLA
• 1993

StrongtalkTM is a typechecker for a downwardcompatible Smalltalk dialect. It is designed for large-scale production software development, and incorporates a strong, modern structural type system. It… (More)

Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration.

• J. R. White, J. M. Lee, +8 authors Henry M. Sarau
• The Journal of biological chemistry
• 1998

Interleukin-8 (IL-8) and closely related Glu-Leu-Arg (ELR) containing CXC chemokines, including growth-related oncogene (GRO)alpha, GRObeta, GROgamma, and epithelial cell-derived… (More)

Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist.

• Henry M. Sarau, David Griswold, +9 authors D. W. P. Hay
• The Journal of pharmacology and experimental…
• 1997

The in vitro and in vivo pharmacological profile of SB 223412 [(S)-(-)-N-(alpha-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carbo xamide], a novel human NK-3 (hNK-3) receptor antagonist, is described.… (More)

Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function.

• A. M. Badger, Jeremy N. Bradbeer, Bart J. Votta, J. C. Lee, Jennifer Adams, David Griswold
• The Journal of pharmacology and experimental…
• 1996

SB 203580 [4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4- pyridyl)imidazole], a selective cytokine suppressive binding protein/p38 kinase inhibitor, was evaluated in several models of cytokine… (More)

SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung.

• D. C. Underwood, Rachel R Osborn, +7 authors David Griswold
• American journal of physiology. Lung cellular and…
• 2000

The effects of a second generation p38 mitogen-activated protein kinase (MAPK) inhibitor, SB 239063 [trans-1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridim idi n-4-yl)imidazole; IC(50)… (More)

Inhibition of p38 MAP kinase as a therapeutic strategy.

• J. C. Lee, S Kumar, David Griswold, D. C. Underwood, Bart J. Votta, Jennifer Adams
• Immunopharmacology
• 2000

Since the discovery of p38 MAP kinase in 1994, our understanding of its biology has progressed dramatically. The key advances include (1) identification of p38 MAP kinase homologs and protein kinases… (More)

Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist.

• Henry M. Sarau, David Griswold, +14 authors D. W. P. Hay
• The Journal of pharmacology and experimental…
• 2000

The pharmacological and pharmacokinetic profile of SB-222200 [(S)-(-)-N-(alpha-ethylbenzyl)-3-methyl-2-phenylquinoline-4-car boxami de], a human NK-3 receptor (hNK-3R) antagonist, was determined.… (More)

Reperfusion increases neutrophils and leukotriene B4 receptor binding in rat focal ischemia.

• Fulvio Barone, Deena Schmidt, +7 authors Henry M. Sarau
• Stroke
• 1992

BACKGROUND AND PURPOSE Neutrophils are critically involved with ischemia and reperfusion injury in many tissues but have not been studied under conditions of reperfusion after focal cerebral… (More)

Bicyclic imidazoles as a novel class of cytokine biosynthesis inhibitors.

• J. C. Lee, A. M. Badger, +6 authors Patrick Bender
• Annals of the New York Academy of Sciences
• 1993

Polymorphonuclear leukocyte infiltration into cerebral focal ischemic tissue: myeloperoxidase activity assay and histologic verification.

• Fulvio Barone, Leonard Hillegass, +6 authors David Griswold
• Journal of neuroscience research
• 1991

Two different techniques were utilized to identify the infiltration of polymorphonuclear leukocytes (PMN) into cerebral tissue following focal ischemia: histologic analysis and a modified… (More)

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