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Neotame is a dipeptide methyl ester derivate. Its chemical structure is N-[N-(3,3dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester. It is intended for use in food as a sweetener and flavour enhancer. Neotame has a sweetness factor approximately 7000 to 13000 times greater than that of sucrose and approximately 30 to 60 times greater than that of(More)
Antibiotic pretreatment significantly altered metabolism of (+)-catechin (cyanidanol-3) in the rat, with decreases in both the urinary elimination of flavanol conjugates and of ring scission of the O-heterocyclic aglycone. The majority of the beta-glucuronidase(s) active in the degradation of flavanol conjugates is associated with the anaerobic microflora(More)
The European Food Safety Authority (EFSA) is asked to advise the Commission on substances used as flavouring substances or present in flavourings or present in other food ingredients with flavouring properties for which existing toxicological data indicate that restrictions of use or presence might be necessary to ensure safety of human health. In(More)
The Panel has been asked to reconsider the possible age-dependent toxicokinetics of BPA in animals and humans and their implication for hazard and risk assessment of BPA in food. The Panel concluded that the exposure of a human fetus to free BPA would be negligible due to the maternal capacity for conjugation whereas the fetal rat would be exposed to free(More)
Following a request from the European Commission to the European Food Safety Authority (EFSA), the Panel on Food Additives and Nutrient Sources added to Food (ANS) was asked to provide a scientific opinion on the safety of magnesium orotate, zinc orotate, calcium orotate, chromium orotate, copper orotate, iron orotate, manganese orotate, potassium orotate,(More)
Metronidazole concentrations in plasma were measured by h.p.l.c. in 12 healthy female volunteers after single and repeated vaginal administration of 500 mg metronidazole pessaries. The area under the plasma concentration-time curve (AUC(0,12 h) was 8.4 +/- 3.9 micrograms ml-1 h (mean +/- s.d.) on day 1 and 20.6 +/- 7.1 micrograms ml-1 h (mean +/- s.d.) on(More)