Adrian Covic8
Andrzej Wiecek7
Gultekin Suleymanlar7
Danilo Fliser7
8Adrian Covic
7Andrzej Wiecek
7Gultekin Suleymanlar
7Danilo Fliser
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This dissertation is the result of my own work and includes nothing which is the outcome of work done in collaboration except where specifically indicated in the text. No parts of this dissertation have been submitted for any other qualification. This dissertation does not exceed the regulation length of 60, 000 words, including tables and footnotes. To(More)
Cardiovascular disease is an important cause of morbidity and mortality in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). All epidemiological studies have clearly shown that accelerated arterial and cardiac aging is characteristic of these populations. Arterial premature aging is heterogeneous. It principally involves the(More)
Over the past decade, the research agenda in dialysis has been dominated by studies on risk factors associated with cardiovascular mortality. It has now become increasingly clear that in dialysis patients, non-cardiovascular causes of death are increased to the same extent as cardiovascular mortality, and therefore research efforts in this area deserve an(More)
At a parcel delivery company, the items being shipped must be sorted by destination. However, the company typically serves more destinations than there are distinct positions for sorting within their sortation. Therefore, several destinations may be assigned to some of the sort positions. It is also possible to assign a single destination to multiple sort(More)
While discussions continue about the precise role of data mining in drug safety, there can be little doubt that data mining algorithms have established themselves as a component of the pharmacovigilance " tool-kit ". The drug safety community should facilitate research into the development and testing of novel data mining and statistical algorithms that(More)
BACKGROUND Cardiovascular events are frequent and vascular endothelial function is abnormal in patients with chronic kidney disease (CKD). We demonstrated endothelial dysfunction with vitamin D deficiency in CKD patients; however the impact of cholecalciferol supplementation on vascular stiffness and vasomotor function, endothelial and bone biomarkers in(More)
Chronic kidney disease is often characterized by enhanced activity of the renin–angiotensin system (RAS) and the sympathetic nervous system. Independent of their effect on blood pressure, these systems also contribute to the pathogenesis of both structural and functional cardiovascular abnormalities and contribute importantly to clinical outcome. There is(More)
Despite many advances in the management of hypertensive chronic kidney disease (CKD) patients, both on and off dialysis, there exist several gaps in our knowledge. Although the modern techniques to measure blood pressure (BP) indirectly have been available for a long time, among those with CKD, how to best assess hypertension and the level to which it(More)
Bidirectional mechanisms exist that link diseases affecting the heart and kidney. This link is complex and remains poorly understood; therefore, charting the shared territory of cardiovascular (CV) and renal medicine poses major problems. Until now, no convincing rationale for delineating new syndromes existed. The multiple connections of the arterial(More)
Hospitalizations due to heart failure are increasing steadily despite advances in medicine. Patients hospitalized for worsening heart failure have high mortality in hospital and within the months following discharge. Kidney dysfunction is associated with adverse outcomes in heart failure patients. Recent evidence suggests that both deterioration in kidney(More)