David Goldenberg

Richard C Friedman2
Robinette Bell2
Elizabeth Haase2
2Richard C Friedman
2Robinette Bell
2Elizabeth Haase
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INTRODUCTION Phosphatidylinositol 3-kinases (PI3Ks) are a group of lipid kinases that regulate signaling pathways involved in cell proliferation, adhesion, survival, and motility. Even though PIK3CA amplification and somatic mutation have been reported previously in various kinds of human cancers, the genetic change in PIK3CA in human breast cancer has not(More)
Related-key attacks are attacks against constructions which use a secret key (such as a blockcipher) in which an attacker attempts to exploit known or chosen relationships among keys to circumvent security properties. Security against related-key attacks has been a subject of study in numerous recent cryptographic papers. However, most of these results are(More)
Tweakable blockciphers, first formalized by Liskov, Rivest, and Wagner [12], are blockciphers with an additional input, the tweak, which allows for variability. An open problem proposed by Liskov et al. is how to construct tweakable blockciphers without using a pre-existing blockcipher. There are many natural questions in this area: is it significantly more(More)
Oropharyngeal cancer represents a growing proportion of head and neck malignancies. This has been associated with the increase in infection of the oropharynx by oncogenic strains of human papillomavirus (HPV). Transoral robotic surgery (TORS) has opened the door for minimally invasive surgery for HPV-related and non-HPV-related oropharyngeal cancer.(More)
BACKGROUND Approximately half of tumor cell lines are resistant to the tumor-selective apoptotic effects of tumor necrosis factor-related apoptosis-inducing ligand (Apo22L/TRAIL). Previously, we showed that combining Apo2L/TRAIL with sorafenib, a multikinase inhibitor, results in dramatic efficacy in Apo2L/TRAIL-resistant tumor xenografts via inhibition of(More)
Determining the positions of the sensor nodes in a network is essential to many network functionalities such as routing, coverage and tracking, and event detection. The localization problem for sensor networks is to reconstruct the positions of all of the sensors in a network, given the distances between all pairs of sensors that are within some radius r of(More)
Sexual behavior over the past year of 32 outpatients with Bipolar disorder is compared to that of 44 Comparison patients that had never had an episode of affective illness. Subjects were outpatients treated with drugs and psychotherapy in routine office practice. Differences in sexual behavior between the two groups as a whole were minimal, but meaningful(More)
The utility and efficacy of prophylactic central neck dissection with total thyroidectomy for the treatment of differentiated thyroid cancer has been debated in the literature over the past few decades. Proponents of prophylactic central neck dissection support its routine use with the notion that it reduces local recurrence, increases accuracy in TNM(More)
While there is consensus that bipolar disorder exists in children and adolescents, its diagnostic criteria are debated. Excessive sexual behavior has been reported in youth who may have juvenile bipolar disorder (JBD), and has been termed "hypersexuality." Although there is no universal definition of this term, this observation has led to a hypothesis that(More)
This dissertation has been read by each member of the following supervisory committee and by majority vote has been found to be satisfactory. in its final form and have found that (1) its format, citations, and bibliographic style are consistent and acceptable; (2) its illustrative materials including figures, tables, and charts are in place; and (3) the(More)