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The swimming behaviour of microorganisms can be strongly influenced by the rhe­ ology of their fluid environment. In this manuscript, we experimentally investigate the effects of shear-thinning viscosity on the swimming behaviour of an undula­ tory swimmer, the nematode Caenorhabditis elegans. Tracking methods are used to measure the swimmer's kinematic(More)
Understanding the relationship between seizure frequency, seizure type and scores obtained from quality of life (QOL) measures is important if the incorporation of QOL measures into epilepsy clinical trials is to become standard practice. There is also a need to consider cross-cultural differences obtained from QOL measures, particularly in the context of(More)
Haploinsufficency of Sim1, which codes for a basic helix-loop-helix-PAS (PER-ARNT-SIM) transcription factor, causes hyperphagia in mice and humans, without decrease in energy expenditure. Sim1 is expressed in several areas of the brain, including the developing and postnatal paraventricular nucleus (PVN), a region of the hypothalamus that controls food(More)
Cancer-related anaemia is associated with a wide spectrum of symptoms that can negatively affect quality of life. Because epoetin alfa has demonstrated efficacy in correcting cancer-related anaemia, the impact of this treatment on quality of life was evaluated in a multinational, randomised, double-blind, placebo-controlled trial in 375 anaemic cancer(More)
Motivated by the observed coordination of nearby beating cilia, we use a scale model experiment to show that hydrodynamic interactions can cause synchronization between rotating paddles driven at constant torque in a very viscous fluid. Synchronization is only observed when the shafts supporting the paddles have some flexibility. The phase difference in the(More)
C. T. Best, M. Studdert-Kennedy, S. Manuel, and J. Rubin-Spitz (1989) reported that listeners given speech labels showed categorical-like perception of a series of complex tone analogs to a /la/-/ra/ speech series, whereas nonspeech listeners were unable to classify the stimuli consistently. In 2 experiments, a new training and testing procedure was used(More)
The replication of human polyomavirus JCV, which causes Progressive Multifocal Leukoencephalopathy, is initiated by the virally encoded T-antigen (T-ag). The structure of the JC virus T-ag origin-binding domain (OBD) was recently solved by X-ray crystallography. This structure revealed that the OBD contains a C-terminal pocket, and that residues from the(More)
Copyright: © 2016 Meinke et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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