David G. Huntsman

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Integrated Genomic Analyses of Ovarian Carcinoma

Stacey Gabriel, Joe W. Gray, +306 authors Jane Peterson
Nature
2011

A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients’ lives. The Cancer Genome Atlas project has analysed… (More)

ARID1A mutations in endometriosis-associated ovarian carcinomas.

Kimberly C. Wiegand, Sohrab P. Shah, +41 authors David G. Huntsman
The New England journal of medicine
2010

BACKGROUND Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis, but the molecular events involved in this transformation have not been described. METHODS We sequenced the… (More)

Familial gastric cancer: overview and guidelines for management.

Carlos Caldas, Fátima Carneiro, +21 authors Charles E. Jackson
Journal of medical genetics
1999

Families with autosomal dominant inherited predisposition to gastric cancer have been described. More recently, germline E-cadherin/CDH1 mutations have been identified in hereditary diffuse gastric… (More)

SNVMix: predicting single nucleotide variants from next-generation sequencing of tumors

Rodrigo Goya, Mark G. F. Sun, +11 authors Sohrab P. Shah
Bioinformatics
2010

MOTIVATION Next-generation sequencing (NGS) has enabled whole genome and transcriptome single nucleotide variant (SNV) discovery in cancer. NGS produces millions of short sequence reads that, once… (More)

Overexpression of the anti-adhesin podocalyxin is an independent predictor of breast cancer progression.

Aruna M Somasiri, Julie S. Nielsen, +9 authors Calvin D Roskelley
Cancer research
2004

Podocalyxin is a CD34-related cell surface molecule with anti-adhesive qualities. We probed a tissue microarray (n = 272) linked to long-term outcome data and found that podocalyxin was highly… (More)

Type Iγ phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with μ1B adaptin

Kun Ling, Shawn F. Bairstow, Chateen Carbonara, Dmitry A. Turbin, David G. Huntsman, Richard A. Anderson
The Journal of cell biology
2007

Assembly of E-cadherin-based adherens junctions (AJ) is obligatory for establishment of polarized epithelia and plays a key role in repressing the invasiveness of many carcinomas. Here we show that… (More)

deFuse: An Algorithm for Gene Fusion Discovery in Tumor RNA-Seq Data

Andrew W McPherson, Fereydoun Hormozdiari, +14 authors Sohrab P. Shah
PLoS Computational Biology
2011

Gene fusions created by somatic genomic rearrangements are known to play an important role in the onset and development of some cancers, such as lymphomas and sarcomas. RNA-Seq (whole transcriptome… (More)

Mutation of FOXL2 in granulosa-cell tumors of the ovary.

Sohrab P. Shah, Martin Köbel, +38 authors David G. Huntsman
The New England journal of medicine
2009

BACKGROUND Granulosa-cell tumors (GCTs) are the most common type of malignant ovarian sex cord-stromal tumor (SCST). The pathogenesis of these tumors is unknown. Moreover, their histopathological… (More)

Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers.

Alireza Heravi-Moussavi, Michael S Anglesio, +31 authors David G. Huntsman
The New England journal of medicine
2012

BACKGROUND Germline truncating mutations in DICER1, an endoribonuclease in the RNase III family that is essential for processing microRNAs, have been observed in families with the pleuropulmonary… (More)

Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling

Ali Bashashati, Gavin Ha, +22 authors Sohrab P. Shah
The Journal of pathology
2013

High-grade serous ovarian cancer (HGSC) is characterized by poor outcome, often attributed to the emergence of treatment-resistant subclones. We sought to measure the degree of genomic diversity… (More)

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