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  • David Johnson, Tim Stack, Russ Fish, Dan Flickinger, Rob Ricci, Jay Lepreau
  • 2006
Simulation has been the dominant research methodology in wireless and sensor networking. When mobility is added, the frequency of real-world experimentation becomes tiny. However , it is becoming clear that simulation models do not sufficiently capture radio and sensor irregularity in a complex, real-world environment, especially indoors. Unfortunately, the(More)
Dedication To My Dearest Tatayya v Acknowledgements I am deeply indebted to my mother, Sita, and my father Ramabhadra Raju, for their continuous support and encouragement throughout my academic career. They have endured many hardships and made sacrifices to educate and provide me the best in education throughout. I am also deeply indebted to my advisor Dr.(More)
Chromatin structure is known to be a barrier to DNA repair and a large number of studies have now identified various factors that modify histones and remodel nucleosomes to facilitate repair. In response to ultraviolet (UV) radiation several histones are acetylated and this enhances the repair of DNA photoproducts by the nucleotide excision repair (NER)(More)
High-throughput molecular profiling data has been used to improve clinical decision making by stratifying subjects based on their molecular profiles. Unsupervised clustering algorithms can be used for stratification purposes. However, the current speed of the clustering algorithms cannot meet the requirement of large-scale molecular data due to poor(More)
High-throughput transcriptomic data generated by microarray experiments is the most abundant and frequently stored kind of data currently used in translational medicine studies. Although microarray data is supported in data warehouses such as tranSMART, when querying relational databases for hundreds of different patient gene expression records queries are(More)
This paper discusses the need for interconnecting computational cancer models from different sources and scales within clinically relevant scenarios to increase the accuracy of the models and speed up their clinical adaptation, validation, and eventual translation. We briefly review current interoperability efforts drawing upon our experiences with the(More)
Livestock grazing is known to influence carbon (C) storage in vegetation and soil. Yet, for grazing management to be used to optimize C storage, large scale investigations that take into account the typically heterogeneous distribution of grazers and C across the landscape are required. In a landscape-scale grazing experiment in the Scottish uplands, we(More)
We have measured the rate constant for the formation of the oxidized chlorophyll a electron donor (P680(+)) and the reduced electron acceptor pheophytin a (-) (Pheo a (-)) following excitation of isolated Photosystem II reaction centers (PS II RC) at 15 K. This PS II RC complex consists of D1, D2, and cytochrome b-559 proteins and was prepared by a(More)
Root litter is the dominant soil carbon and nutrient input in many ecosystems, yet few studies have considered how root decomposition is regulated at the landscape scale and how this is mediated by land-use management practices. Large herbivores can potentially influence below-ground decomposition through changes in soil microclimate (temperature and(More)
Multiscale models are commonplace in cancer modeling, where individual models acting on different biological scales are combined within a single, cohesive modeling framework. However, model composition gives rise to challenges in understanding interfaces and interactions between them. Based on specific domain expertise, typically these computational models(More)