David G. Durand

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While the age-related loss in muscle mass partially explains the decline in strength, other yet undefined mechanisms contribute. This study investigates whether changes in myosin-actin stoichiometry and oxidative modification could help explain the decrement in muscle strength with aging. Protein expression and oxidation were evaluated in myosin and actin(More)
Do body size components, such as weights of internal organs and long bone lengths, with different functions and different developmental histories also have different genetic architectures and pleiotropic patterns? We examine murine quantitative trait loci (QTL) for necropsy weight, four long bone lengths, and four organ weights in the LG/J × SM/J(More)
Introduction The issue of what text really is, and how it affects our notions of proper text representation has been with us almost from the beginning of text encoding [Goldfarb 1981, Reid 1980, Coombs, et al. 1987, DeRose, et al. 1990, Renear et al.]. The simplest reasonable view, that text is fundamentally an ordered hierarchical structure, determined by(More)
This paper describes the Palimpsest data model, which describes flexible merging and tracking of individual changes to shared hypertext or multimedia documents. Palimpsest is designed to represent and manage the sorts of versioning problems that will inevitably occur in distributed collaborative manipulation of shared data. In fact, in a cooperative editing(More)
A document that is in active use is generally one that is changing. Version control provides one way to control the disruptive effects of change without the worse solution of preventing or obstructing it. This panel will examine the relevance and problems of version control, with an emphasis on the topic of collaboration support. Despite ha long history in(More)
THE WAY IN WHICH TEXT IS represented on a computer affects the kinds of uses to which it can be put by its creator and by subsequent users. The electronic document model currently in use is impoverished and restrictive. The authors argue that text is best represented as an ordered hierarchy of content object (OHCO), because that is what text really is. This(More)
The aim of this study was to develop and analyze in vitro azithromycin (AZM)-resistant mutants of Escherichia coli and Shigella boydii. Three clinical isolates of E. coli and one S. boydii isolated from feces samples collected from children under 5 years of age with diarrhea in Lima, Peru were inoculated onto Mueller-Hinton plates containing increasing(More)