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Studies of iron overload in humans and animals suggest that brain iron concentrations may be related in a regionally specific way to body iron status. However, few quantitative studies have investigated the associations between peripheral and regional brain iron in a normal elderly cohort. To examine these relationships, we used MRI to measure the proton(More)
Non-insulin-dependent diabetes mellitus is an increasingly prevalent disease in Western and developing societies. A major metabolic abnormality of non-insulin-dependent diabetes is impaired insulin action (insulin resistance). Diets high in fat from vegetable and nonaquatic animal sources (rich in linoleic acid, an omega-6 fatty acid, and saturated fats)(More)
The validity, sensitivity, and specificity of depressive symptoms for the diagnosis of major depression, minor depression, dysthymic disorder, and subsyndromal depression in Parkinson's disease (PD) were examined. A consecutive series of 173 patients with PD attending a Movement Disorders Clinic underwent a comprehensive psychiatric and neurological(More)
OBJECTIVES To understand how carers of dementia sufferers gain access to community support and to determine potential barriers for carers. DESIGN Qualitative study using semi-structured interviews of carers after an Aged Care Assessment Team intervention. SETTING Australian metropolitan Aged Care Assessment Team. SUBJECTS 24 live-in carers of dementia(More)
OBJECTIVE The purpose of this study was to determine longitudinal predictors of cognitive decline in older individuals with diabetes who did not have dementia. RESEARCH DESIGN AND METHODS Cognitive assessments were performed in 205 subjects with diabetes (mean age 75.3 years) and repeated a median 1.6 years later. The sample was drawn from an existing(More)
Low levels of serum adiponectin have been linked to central obesity, insulin resistance, metabolic syndrome, and type 2 diabetes. Variants in ADIPOQ, the gene encoding adiponectin, have been shown to influence serum adiponectin concentration, and along with variants in the adiponectin receptors (ADIPOR1 and ADIPOR2) have been implicated in metabolic(More)
OBJECTIVES To investigate the circumstances that led general practitioners to refer dementia sufferers and their carers to community support services. DESIGN Qualitative study using semi-structured interviews, carried out between 1 September 1999 and 30 April 2000. SETTING AND PARTICIPANTS 21 live-in carers of patients with dementia referred for the(More)
BACKGROUND/AIM To use health record data linkage to improve case ascertainment and death rate estimates of deaths with dementia. METHODS Retrospective population study. Western Australians older than 20 years who died between 1990 and 2005 with a dementia diagnosis in Western Australian hospitals and/or death records using the Western Australian Data(More)
BACKGROUND The Australian Pharmaceutical Benefits Scheme (PBS) first subsidized cholinesterase inhibitors (CEIs) for Alzheimer's disease in 2001, introducing a novel therapy for a previously untreatable common condition. This study aims to determine Australian rates of CEI use and to assess equality of access to treatment based on socioeconomic status and(More)
The notion that a defect in hypothalamic function may be a critical factor in the aetiology of obesity and diabetes stems from observations of the important role that this brain region plays in both the behavioural and metabolic events related to feeding and energy balance. Sensory events associated with the beginning of a meal trigger a series of metabolic(More)