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Studies of iron overload in humans and animals suggest that brain iron concentrations may be related in a regionally specific way to body iron status. However, few quantitative studies have investigated the associations between peripheral and regional brain iron in a normal elderly cohort. To examine these relationships, we used MRI to measure the proton(More)
OBJECTIVE The purpose of this study was to determine longitudinal predictors of cognitive decline in older individuals with diabetes who did not have dementia. RESEARCH DESIGN AND METHODS Cognitive assessments were performed in 205 subjects with diabetes (mean age 75.3 years) and repeated a median 1.6 years later. The sample was drawn from an existing(More)
Low levels of serum adiponectin have been linked to central obesity, insulin resistance, metabolic syndrome, and type 2 diabetes. Variants in ADIPOQ, the gene encoding adiponectin, have been shown to influence serum adiponectin concentration, and along with variants in the adiponectin receptors (ADIPOR1 and ADIPOR2) have been implicated in metabolic(More)
OBJECTIVES To investigate the circumstances that led general practitioners to refer dementia sufferers and their carers to community support services. DESIGN Qualitative study using semi-structured interviews, carried out between 1 September 1999 and 30 April 2000. SETTING AND PARTICIPANTS 21 live-in carers of patients with dementia referred for the(More)
BACKGROUND/AIM To use health record data linkage to improve case ascertainment and death rate estimates of deaths with dementia. METHODS Retrospective population study. Western Australians older than 20 years who died between 1990 and 2005 with a dementia diagnosis in Western Australian hospitals and/or death records using the Western Australian Data(More)
PURPOSE Chronic Hepatitis C Virus (HCV)-infected patients with liver cirrhosis (LC) respond poorly to interferon-alpha (IFN-α) and ribavirin (RBV) combination therapy, but the reason for this is unclear. We previously reported that HCV-infection induces endoplasmic reticulum (ER) stress and autophagy response that selectively down regulates the type I IFN-α(More)
OBJECTIVE To examine the association of mid-life exposure to several psychiatric disorders with the development of late-life dementia. METHODS A matched case-control study using Western Australian state-wide hospital inpatient, outpatient mental health and emergency records linked to death records. Incident dementia cases (2000-2009) aged 65 to 84 years(More)
OBJECTIVE To determine whether disparities in the nature and management of type 2 diabetes persist between Aboriginal and the majority Anglo-Celt patients in an urban Australian community. RESEARCH DESIGN AND METHODS Baseline data from the observational Fremantle Diabetes Study collected from 1993 to 1996 (phase I) and from 2008 to 2011 (phase II) were(More)
BACKGROUND While depression is a frequent psychiatric comorbid condition in diabetes and has significant clinical impact, the syndromal profile of depression and anxiety symptoms has not been examined in detail. AIMS To determine the syndromal pattern of the depression and anxiety spectrum in a large series of patients with type 2 diabetes, as determined(More)
AIMS/HYPOTHESIS To assess whether self-monitoring of blood glucose (SMBG) is an independent predictor of improved outcome in a community-based cohort of type 2 diabetic patients. MATERIALS AND METHODS We used longitudinal data from (1) 1,280 type 2 diabetic participants in the observational Fremantle Diabetes Study (FDS) who reported SMBG and diabetes(More)