David G. Bruce

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AIMS To investigate ethnic/racial differences in the prevalence of serum antibodies to glutamic acid decarboxylase (GADA) and ICA512/IA-2 in diabetic patients from a large, urban community. METHODS A cross-sectional sample of 1,381 diabetic patients aged 11-98 years, representing 61% of those identified in a postcode-defined population base of 120,097(More)
Non-insulin-dependent diabetes mellitus is an increasingly prevalent disease in Western and developing societies. A major metabolic abnormality of non-insulin-dependent diabetes is impaired insulin action (insulin resistance). Diets high in fat from vegetable and nonaquatic animal sources (rich in linoleic acid, an omega-6 fatty acid, and saturated fats)(More)
OBJECTIVES To determine longitudinal predictors of incident and persistent fear of falling (FOF) in older women. DESIGN Longitudinal study. SETTING Clinical research center based at a university hospital. PARTICIPANTS One thousand two hundred eighty-two community-dwelling women aged 70 to 85. MEASUREMENTS FOF at baseline and after 3 years of(More)
OBJECTIVES To examine whether fear of falling is a probable cause of reduced recreational physical activity levels in healthy older women. DESIGN Cross-sectional analysis of baseline data from a longitudinal study. PARTICIPANTS One thousand five hundred older, ambulatory women (aged 70-85), selected at random from the electoral roll. MEASUREMENTS(More)
OBJECTIVE To determine whether the prevalence of dementia, depression and/or disability in older diabetic subjects warrants an active screening approach by diabetes health care workers. PATIENTS AND METHODS The initial 223 members of a cohort of 529 eligible diabetic subjects, aged 70 years or over, were screened for cognitive impairment (using the(More)
The aims of this study were to assess the incidence, predictors, consequences, and inpatient cost of lower extremity amputation (LEA) in a community-based cohort of type 2 diabetic patients. Between 1993 and 1996, 1,294 patients with type 2 diabetes were recruited to the longitudinal, observational Fremantle Diabetes Study. LEAs and mortality from cardiac(More)
Anosognosia and apathy are among the most common behavioral and psychological disorders of Alzheimer's disease and are significantly associated in cross-sectional studies. The aim for this study was to carry out for the first time a longitudinal assessment of this association with the aim of clarifying the predictive role between anosognosia and apathy in(More)
Depression is associated with excess mortality in patients with type 2 diabetes. We investigated the impact, and possible causal mechanisms, of depression on all-cause and cardiac mortality in patients with type 2 diabetes. We recruited 1,273 patients with type 2 diabetes from a postcode-defined community (average age 64.1±11.2 years, 48.7% males, median(More)
OBJECTIVE To study the clinical contexts contributing to harmful medication errors. DESIGN, SETTING AND PARTICIPANTS A qualitative study using semi-structured interviews was conducted between March and August 2005 at Fremantle Hospital, a 450-bed metropolitan teaching hospital. Twenty-six of 46 staff members (57%) identified by pharmacy staff as having(More)