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We believe that navigation in information spaces is best supported by tapping into our natural spatial and geographic ways of thinking. To this end, we are developing a new computer interface model called Pad. The ongoing Pad project uses a spatial metaphor for computer interface design. It provides an intuitive base for the support of such applications as(More)
A core principle of Agile development is to satisfy the customer by providing valuable software on an early and continuous basis. For a software application to be valuable it should have a user interface that is usable. Recently there has been some evidence that suggests using Agile methods alone does not ensure that an applications UI is usable. As a(More)
The RightPages electronic library prototype system, which gives users full online library services, is described. The prototype takes advantage of fast hardware, multimedia workstations, and broadband networks to process scientific and technical journals for users and to offer a service that: alerts them to the arrival of new journal articles matching their(More)
Since the publication of the first paper on Magic Lenses, various methods have been proposed for implementing lenses which filter the objects seen through them However, all the methods proposed stier from various flaws. In particular, none of these methods solve the problem of composing lenses in a general way. A method which solves all these problems is(More)
Because a very large number of gene expression data sets are currently publicly available, comparisons across experiments between different laboratories have become a common task. However, most existing methods of comparing gene expression data sets require setting arbitrary cutoffs (e.g., for statistical significance or fold change), which could select(More)
We investigate the biological effects of radiation using adult Drosophila melanogaster as a model organism, focusing on gene expression and lifespan analysis to determine the effect of different radiation doses. Our results support a threshold effect in response to radiation: no effect on lifespan and no permanent effect on gene expression is seen at(More)
Previous research has shown that gold nanoparticles can increase the effectiveness of radiation on cancer cells. Improved radiation effectiveness would allow lower radiation doses given to patients, reducing adverse effects; alternatively, it would provide more cancer killing at current radiation doses. Damage from radiation and gold nanoparticles depends(More)
This paper describes Minerva, an interactive tour-guide robot that was successfully deployed in a Smithsonian museum. Minerva’s software is pervasively probabilistic, relying on explicit representations of uncertainty in perception and control. During 2 weeks of operation, the robot interacted with thousands of people, both in the museum and through the(More)
Environmental and genetic interventions extend health span in a range of organisms by triggering changes in different specific but complementary pathways. We investigated the gene expression changes that occur across species when health span is extended via different interventions. To perform this comparison using heterogeneous datasets from different(More)
We report the results of a 30 ks Chandra/ACIS-S observation of the isolated compact object 1RXS J141256.0+792204 (Calvera). The X-ray spectrum is adequately described by an absorbed neutron star hydrogen atmosphere model with kT eff = 88.3 ± 0.8 eV and radiation radius R /d = 4.1 ± 0.1 km kpc. The best-fit blackbody spectrum yields parameters consistent(More)