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Ribosomal loci represent a major tool for investigating environmental diversity and community structure via high-throughput marker gene studies of eukaryotes (e.g. 18S rRNA). Since the estimation of species' abundance is a major goal of environmental studies (by counting numbers of sequences), understanding the patterns of rRNA copy number across species(More)
The renin–angiotensin–aldosterone system (RAAS) is not the sole, but perhaps the most important volume regulator in vertebrates. To gain insights into the function and evolution of its components, we conducted a phylogenetic analysis of its main related genes. We found that important parts of the system began to appear with primitive chordates and tunicates(More)
Advection-diffusion models have been used successfully to describe the time and place of recapture of tuna tagged with conventional dart tags. Such models are the continuous analogs of a biased random walk. This paper demonstrates how biased random walks can be used to simulate large scale movements of tunas as recorded by archival tags in a way that(More)
Secundum-type atrial septal defects (ASDII) account for approximately 10% of all congenital heart defects (CHD) and are associated with a familial risk. Mutations in transcription factors represent a genetic source for ASDII. Yet, little is known about the role of mutations in sarcomeric genes in ASDII etiology. To assess the role of sarcomeric genes in(More)
Alpha-solenoids are flexible protein structural domains formed by ensembles of alpha-helical repeats (Armadillo and HEAT repeats among others). While homology can be used to detect many of these repeats, some alpha-solenoids have very little sequence homology to proteins of known structure and we expect that many remain undetected. We previously developed a(More)
SUMMARY Protein features are often displayed along the linear sequence of amino acids that make up that protein, but in reality these features occupy a position in the folded protein's 3D space. Mapping sequence features to known or predicted protein structures is useful when trying to deduce the function of those features and when evaluating sequence or(More)
In this paper, a general framework of acoustic-phonetic modelling is developed. Context sensitive rules are incorporated into a knowledge-based automatic speech recognition (ASR) system and are assessed with control based on fuzzy decision making. The reliability measure is outlined: a tests collection is run and a confusion matrix is built for each rule.(More)
We show that the fitting of nonlinear hierarchical random effects models by maximum likelihood can be made automatic to the same extent that Bayesian model fitting can be automated by the program BUGS. The word 'automatic' here means that the technical details of computation are made transparent to the user. We achieve this by combining a technique from(More)
During meiosis, homologous chromosomes associate to form the synaptonemal complex (SC), a structure essential for fertility. Information about the epigenetic features of chromatin within this structure at the level of superresolution microscopy is largely lacking. We combined single-molecule localization microscopy (SMLM) with quantitative analytical(More)