David Floyd

Learn More
New therapeutics to combat malaria are desperately needed. Here we show that the enzyme protein farnesyltransferase (PFT) from the malaria parasite Plasmodium falciparum (P. falciparum) is an ideal drug target. PFT inhibitors (PFTIs) are well tolerated in man, but are highly cytotoxic to P. falciparum. Because of their anticancer properties, PFTIs comprise(More)
resources of the entire scientific and technical communities to bear on national problems through its volunteer advisory committees. The Transportation Research Board is distributing this Circular to make the information contained herein available for use by individual practitioners in state and local transportation agencies, researchers in academic(More)
Occupancy sensors have the potential to significantly reduce energy use by switching off electrical loads when a normally occupied area is vacated. While occupancy sensors can be used to control a variety of load types, their most popular use has been to control lighting in commercial buildings. Manufacturers claim savings of 15% to 85%, although there is(More)
We present an interesting method of shaping a vascularized medial femoral condyle (MFC) flap into a "neophalanx" for phalangeal reconstruction. Our patient presented with limited strength and function secondary to fracture nonunion of the proximal phalanx of the dominant thumb. Following excision of the pseudarthrosis, an MFC corticoperiosteal flap was(More)
We present newly acquired images of the near-infrared counterpart of 3CR radio sources. All the sources were selected to have a redshift of less than 0.3 to allow us to obtain the highest spatial resolution. The observations were carried out as a snapshot program using the Near-Infrared Camera and Multiobject Spectrograph (NICMOS) on-board the Hubble Space(More)
Preoperative perforator marking for deep inferior epigastric artery perforator flaps is vital to the success of the procedure in breast reconstruction. Advances in imaging have facilitated accurate identification and preselection of potentially useful perforators. However, the reported imaging accuracy may be lost when preoperatively marking the patient,(More)
We have used an analysis of signal and variation in motor behavior to elucidate the organization of the cerebellar and brainstem circuits that control smooth pursuit eye movements. We recorded from the Abducens nucleus, identified floccular target neurons (FTNs), and other, non-FTN vestibular neurons. First, we assessed neuron-behavior correlations, defined(More)
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. ABSTRACT The Magellan Baade and Clay telescopes regularly produce images of(More)