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Stress is a response to change from the norm. Stress affects all individuals to varying degrees and can be positive, such as eustress, or negative, such as distress. The purpose of this qualitative, cross-sectional study was to investigate the stressors of the typical student registered nurse anesthetist (SRNA), with the objective of identifying trends in(More)
Substituted tetrahydroquinolines (THQs) have been previously identified as inhibitors of mammalian protein farnesyltransferase (PFT). Previously we showed that blocking PFT in the malaria parasite led to cell death and that THQ-based inhibitors are the most potent among several structural classes of PFT inhibitors (PFTIs). We have prepared 266 THQ-based(More)
New therapeutics to combat malaria are desperately needed. Here we show that the enzyme protein farnesyltransferase (PFT) from the malaria parasite Plasmodium falciparum (P. falciparum) is an ideal drug target. PFT inhibitors (PFTIs) are well tolerated in man, but are highly cytotoxic to P. falciparum. Because of their anticancer properties, PFTIs comprise(More)
OBJECTIVES To evaluate the role of radical surgical debridement and excision with a vertical rectus abdominis myocutaneous (VRAM) flap reconstruction in patients with advanced penile cancer and subcutaneous metastatic disease, as the quality of life in such patients is extremely poor, multimodal treatments often fail and the outlook for the patient is(More)
New antimalarials are urgently needed. We have shown that tetrahydroquinoline (THQ) protein farnesyltransferase (PFT) inhibitors (PFTIs) are effective against the Plasmodium falciparum PFT and are effective at killing P. falciparum in vitro. Previously described THQ PFTIs had limitations of poor oral bioavailability and rapid clearance from the circulation(More)
OBJECTIVE To identify major risk factors for Yersinia enterocolitica (YE) and identify measures to reduce YE infections. METHODS A prospective case control study, group age matched, using 186 cases of YE identified by community pathology laboratories and 379 randomly selected controls. Conducted between April 1995 and June 1996 in Auckland, New Zealand.(More)
resources of the entire scientific and technical communities to bear on national problems through its volunteer advisory committees. The Transportation Research Board is distributing this Circular to make the information contained herein available for use by individual practitioners in state and local transportation agencies, researchers in academic(More)
BACKGROUND Widespread adoption of the extended latissimus dorsi myocutaneous flap in breast reconstruction has been limited by donor-site complications. The dissection plane may be either above or below the superficial layer of the thoracolumbar fascia, which may be transferred with the flap or retained on the back skin flaps. The aim of this study was to(More)
Occupancy sensors have the potential to significantly reduce energy use by switching off electrical loads when a normally occupied area is vacated. While occupancy sensors can be used to control a variety of load types, their most popular use has been to control lighting in commercial buildings. Manufacturers claim savings of 15% to 85%, although there is(More)
Reconstruction of the inframammary fold (IMF) during breast reconstruction is vital in achieving good aesthetic outcomes and avoiding further corrective surgery. The IMF is usually reconstructed by comparing with the other side and estimating its correct position. The IMF template can be used to accurately and consistently mark the position of the IMF(More)