Sort by:

• Highly Influential Citations
• Citations
• Acceleration
• Velocity
• Recency

Learn More

Repression of Heat Shock Transcription Factor HSF1 Activation by HSP90 (HSP90 Complex) that Forms a Stress-Sensitive Complex with HSF1

• Jiangying Zou, Yongle Guo, Toumy Guettouche, David F. Smith, Richard Voellmy
• Cell
• 1998

Heat shock and other proteotoxic stresses cause accumulation of nonnative proteins that trigger activation of heat shock protein (Hsp) genes. A chaperone/Hsp functioning as repressor of heat shock… (More)

The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo.

• Daniel L. Riggs, Patricia J Roberts, +6 authors David F. Smith
• The EMBO journal
• 2003

Hsp90 is required for the normal activity of steroid receptors, and in steroid receptor complexes it is typically bound to one of the immunophilin-related co-chaperones: the peptidylprolyl isomerases… (More)

Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E

• Yuqing Huo, Andreas Schober, +6 authors Klaus Ley
• Nature Medicine
• 2003

We studied whether circulating activated platelets and platelet–leukocyte aggregates cause the development of atherosclerotic lesions in apolipoprotein-E–deficient (Apoe−/−) mice. Circulating… (More)

Galectin-1, -2, and -3 exhibit differential recognition of sialylated glycans and blood group antigens.

• Sean R Stowell, Connie M Arthur, +5 authors Richard D. Cummings
• The Journal of biological chemistry
• 2008

Human galectins have functionally divergent roles, although most of the members of the galectin family bind weakly to the simple disaccharide lactose (Galbeta1-4Glc). To assess the specificity of… (More)

Hop as an adaptor in the heat shock protein 70 (Hsp70) and hsp90 chaperone machinery.

• S C Chen, David F. Smith
• The Journal of biological chemistry
• 1998

Hop, an abundant and conserved protein of unresolved function, binds concomitantly with heat shock protein 70 (Hsp70) and Hsp90, participates with heat shock proteins at an intermediate stage of… (More)

Identification of a specific glycoprotein ligand for P-selectin (CD62) on myeloid cells

• Kevin L. Moore, Nancy L. Stults, +4 authors Rodger P McEver
• The Journal of cell biology
• 1992

P-selectin (CD62, GMP-140, PADGEM), a Ca(2+)-dependent lectin on activated platelets and endothelium, functions as a receptor for myeloid cells by interacting with sialylated, fucosylated… (More)

Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes.

• Cindy R Sinars, Joyce Cheung-Flynn, Ronald A. Rimerman, Jonathan G. Scammell, David F. Smith, Jon Clardy
• Proceedings of the National Academy of Sciences…
• 2003

The ability to bind immunosuppressive drugs such as cyclosporin and FK506 defines the immunophilin family of proteins, and the FK506-binding proteins form the FKBP subfamily of immunophilins. Some… (More)

Squirrel monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor binding.

• Wesley B. Denny, Donna L Valentine, P. Dominic Reynolds, David F. Smith, Jonathan G. Scammell
• Endocrinology
• 2000

Squirrel monkeys have high circulating cortisol to compensate for expression of low-affinity glucocorticoid receptors (GRs). We have demonstrated that the FK506-binding immunophilin FKBP51 is… (More)

Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes.

• David F. Smith
• Molecular endocrinology
• 1993

A cell-free system was used to examine heat shock protein 90 (hsp90)-progesterone receptor (PR) binding at near physiological conditions. Four major findings are presented: 1) hsp90 is required to… (More)

Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung.

• Jörg Reutershan, Margaret A. Morris, +4 authors Klaus Ley
• The Journal of clinical investigation
• 2006

In models of acute lung injury, CXC chemokine receptor 2 (CXCR2) mediates migration of polymorphonuclear leukocytes (PMNs) into the lung. Since CXCR2 ligands, including CXCL1 and CXCL2/3, are… (More)

• ‹
• 1
• 2
• 3
• 4
• 5
• ›