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- David F. Fiorentino, Albert Zlotnik, Tim R. Mosmann, Maureen Howard, Anne O'Garra
- Journal of immunology
- 1991
IL-10 inhibits the ability of macrophage but not B cell APC to stimulate cytokine synthesis by Th1 T cell clones. In this study we have examined the direct effects of IL-10 on both macrophage cell… (More)
- David F. Fiorentino, Martha W Bond, Tim R. Mosmann
- The Journal of experimental medicine
- 1989
A cytokine synthesis inhibitory factor (CSIF) is secreted by Th2 clones in response to Con A or antigen stimulation, but is absent in supernatants from Con A-induced Th1 clones. CSIF can inhibit the… (More)
- David F. Fiorentino, Albert Zlotnik, +4 authors Anne O'Garra
- Journal of immunology
- 1991
Murine IL-10 (cytokine synthesis inhibitory factor) inhibits cytokine production by Th1 cell clones when they are activated under conditions requiring the presence of APC. By preincubating APC with… (More)
Complementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis by TH1 helper T cells, were isolated and expressed. The… (More)
- Paulo Vieira, René de Waal-Malefyt, +7 authors Kevin W. Moore
- Proceedings of the National Academy of Sciences…
- 1991
We have demonstrated the existence of human cytokine synthesis inhibitory factor (CSIF) [interleukin 10 (IL-10)]. cDNA clones encoding human IL-10 (hIL-10) were isolated from a tetanus toxin-specific… (More)
- Steffan N. Ho, Neil A. Clipstone, +5 authors Gerald R Crabtree
- Clinical immunology and immunopathology
- 1996
The immunosuppressants cyclosporin A (CsA), FK506, and rapamycin suppress the immune response by inhibiting evolutionary conserved signal transduction pathways. CsA, FK506, and rapamycin bind to… (More)
- Tim R. Mosmann, J H Schumacher, +7 authors David F. Fiorentino
- Immunological reviews
- 1991
- Emanual Maverakis, Forum B Patel, +13 authors M Eric Gershwin
- Journal of autoimmunity
- 2014
Vasoconstriction accompanied by changes in skin color is a normal physiologic response to cold. The distinction between this normal physiology and Raynaud's phenomenon (RP) has yet to be well… (More)
The rapamycin-sensitive signaling pathway is required to transduce specific mitogenic signals to the cell cycle machinery responsible for G1 progression. Genetic studies in yeast identified two… (More)
- David F. Fiorentino, Lorinda S Chung, Jeff Zwerner, Antony Rosen, Livia A. Casciola-Rosen
- Journal of the American Academy of Dermatology
- 2011
BACKGROUND
Dermatomyositis (DM) is a multisystem autoimmune disease, in which serologic evidence of immune responses to disease-specific antigenic targets is found in approximately 50% to 70% of… (More)