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CONTEXT The terrorist attacks of September 11, 2001, represent an unprecedented exposure to trauma in the United States. OBJECTIVES To assess psychological symptom levels in the United States following the events of September 11 and to examine the association between postattack symptoms and a variety of indices of exposure to the events. DESIGN(More)
The oxygen dependence of mitochondrial respiration was investigated using suspensions of mitochondria and quiescent ventricular myocytes isolated from adult rat hearts. A new optical method was used to determine oxygen concentration in the suspending media. The P50 for respiration for coupled mitochondria at a high [ATP]/[ADP].[Pi] ratio and oxidizing(More)
Changes in cerebral blood flow (CBF) using laser-Doppler and microvascular O2 oxygen tension using oxygen-dependent phosphorescence quenching in the rat somatosensory cortex were obtained during electrical forepaw stimulation. The signal-averaged CBF response resulting from electrical forepaw stimulation consisted of an initial peak (t = 3.1 +/- 0.8 seconds(More)
Oxygen-dependent quenching of phosphorescence has been used to measure the dependence of mitochondrial oxidative phosphorylation on oxygen concentration in suspensions of isolated rat liver mitochondria. An instrument has been designed which simultaneously monitors the phosphorescence lifetime of a fluorophor and the reduction of cytochrome c by dual(More)
The energy relationships between cytosolic and mitochondrial metabolism were studied in the hearts from euthyroid, hypothyroid, and hyperthyroid rats. Isolated mitochondria showed high respiratory control ratios and impermeability to exogenous NADH. Hypo- and hyperthyroidism, respectively, resulted in lower and higher contents of both cytochromes per(More)
Isolated rat heart was perfused with Langendorff's retrograde perfusion method, while the oxygen consumption and the left ventricular pressure were monitored continually. The steady-state contents of metabolites in the cardiac tissue, freeze clamped under various work-load conditions, were determined and the concentrations of free cytosolic ADP and AMP were(More)
Enzymatically prepared split frog skins consisted purely of epithelial cells. Electrical parameters and the cell contents of ATP, ADP, phosphocreatine (PCr), creatine, inorganic phosphate, protein, and water were measured in skins maintained at room temperature. Studies were conducted under base-line conditions, 15 and 60 min after adding vasopressin, and(More)
The present study describes the relationships of extracellular striatal dopamine, cortical oxygen pressure, and striatal hydroxyl radicals in brain of newborn piglets during hypoxia and posthypoxic reoxygenation. Hypoxia was induced by reducing the fraction of inspired oxygen (FiO2) from 22% (control) to 7% for 1 h. The FiO2 was then returned to the control(More)
One of the characteristic features of living matter is its ability to generate metabolic energy which is required for growth and the maintenance of multiple cellular functions. The major pathways whereby eukaryotic organisms produce energy are glycolysis and mitochondrial oxidative phosphorylation; the latter process, which involves complete combustion of(More)