David Eric Holt

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Esophageal hiatal hernia was diagnosed in 11 young Chinese Shar-Pei dogs between October 1985 and July 1991. The dogs ranged in age from 2 to 11 months and included 3 females and 8 males. The most common clinical signs were regurgitation, vomiting, and hypersalivation. Physical examination was normal in 6 dogs; abnormal physical examination findings in the(More)
OBJECTIVE To determine the prevalence of exposure to canine influenza virus (CIV) in dogs in a metropolitan animal shelter. DESIGN Serologic survey. ANIMALS 74 dogs. PROCEDURES Dogs were randomly selected from the canine shelter population. A physical examination was performed, and blood samples were obtained and submitted for serologic testing for(More)
BACKGROUND Over 80,000 people undergo pulmonary resection for a lung nodule in the United States each year. Small nodules are frequently missed or difficult to find despite preoperative imaging. We hypothesized that near-infrared (NIR) imaging technology could be used to identify and locate lung nodules during surgery. METHODS We enrolled 18 patients who(More)
Many cats have one or two episodes of constipation without further recurrence, although others progress to complete colonic failure. Middle-aged male cats are particularly at risk for the clinical continuum of constipation, obstipation, and dilated megacolon. Pelvic canal stenosis and nerve injury are minor causes in the development of this syndrome. In(More)
OBJECTIVE To determine whether glutamine (GLN), tryptophan (TRP), and tryptophan metabolite concentrations are higher in cerebralspinal fluid (CSF) dogs with naturally occurring portosystemic shunts (PSS), compared with control dogs. ANIMALS 11 dogs with confirmed PSS and 12 control dogs fed low- and high-protein diets. PROCEDURE Cerebrospinal fluid and(More)
Results of abdominal ultrasonography in 63 dogs and cats with suspected congenital portosystemic shunts (PSS) were compared with surgical, portographic, and necropsy findings. True-positive ultrasonographic results were found in 33 animals, and 2 animals had false-positive results for detection of single extrahepatic PSS. In 4 animals, results were true(More)
This retrospective study describes the clinical course, treatment, and outcome of 21 dogs with gastric adenocarcinomas (n=19) and leiomyosarcomas (n=2). Medical records from 1986 to 1999 were reviewed for signalment, weight, diagnosis, tumor location, clinical signs, radiographic imaging procedures, surgical procedures, chemotherapy, duration of follow-up(More)
Extrahepatic biliary obstruction (EHBO) was confirmed at surgery or necropsy in 22 cats. Biliary or pancreatic adenocarcinoma was diagnosed by histopathology in six cats and one cat had an undiagnosed mass in the common bile duct. The remaining 15 cats had at least one of a complex of inflammatory diseases including pancreatitis, cholangiohepatitis,(More)
Canine X-linked severe combined immunodeficiency (XSCID) is due to mutations in the common gamma chain (gammac) gene and is identical clinically and immunologically to human XSCID, making it a true homologue of the human disease. Bone marrow-transplanted (BMT) XSCID dogs not only engraft donor T cells and reconstitute normal T-cell function but, in contrast(More)