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Objective.  The safety and efficacy of intrathecal (IT) ziconotide was studied in a randomized, double-blind, placebo-controlled trial. Materials and Methods.  Patients (169 ziconotide, 86 placebo) with severe chronic nonmalignant pain unresponsive to conventional therapy and a visual analog scale of pain intensity (VASPI score) ≥ 50 mm were treated over a(More)
Safety and efficacy data from a study of slow intrathecal (IT) ziconotide titration for the management of severe chronic pain are presented. Patients randomized to ziconotide (n = 112) or placebo (n = 108) started IT infusion at 0.1 microg/hour (2.4 microg/day), increasing gradually (0.05-0.1 microg/hour increments) over 3 weeks. The ziconotide mean dose at(More)
A set of permutations I ⊂ S n is said to be k-intersecting if any two permutations in I agree on at least k points. We show that for any k ∈ N, if n is sufficiently large depending on k, then the largest k-intersecting subsets of S n are cosets of stabilizers of k points, proving a conjecture of Deza and Frankl. We also prove a similar result concerning(More)