David E Sims

Learn More
Gap junctions have been described ultrastructurally between neurons and epitheliomuscular cells and between neurons and their processes in the hypostome, peduncle and basal disc of Hydra. All gap junctions examined in Hydra exhibit two apposed plasma membranes having a 2-4 nm gap continuous with the extracellular space. The gap junctions are variable in(More)
The acute effects of interleukin 2 (IL-2) were determined in the rat cremaster microcirculation model by intravital, light, and electron mi croscopy to better understand the pathophysiology of the IL-2-induced vascular leak syndrome. Four groups of rats were studied over a 2-h monitoring period. One group received 1 x II)1' units of IL-2/kg i.v. (n = 10),(More)
Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) are a polymorphic group of clinical disorders comprising the major cause of renal failure in children. Included within CAKUT is a wide spectrum of developmental malformations ranging from renal agenesis, renal hypoplasia and renal dysplasia (maldifferentiation of renal tissue), each characterized(More)
  • 1