David E. Rourke

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The intellectual performance of 350 patients with seizures was examined. Seizures were classified according to the revised International Classification of Epileptic Seizures as partial (simple or complex), generalized, or partial secondarily generalized. Performance on the Wechsler Intelligence subtests served to measure intellectual ability. Patients with(More)
Telomeres, the end of chromosomes, are organized in a nonoverlapping fashion and form microterritories in nuclei of normal cells. Previous studies have shown that normal and tumor cell nuclei differ in their 3D telomeric organization. The differences include a change in the spatial organization of the telomeres, in telomere numbers and sizes and in the(More)
Twenty right-handed male and female subjects were asked for ear-by-ear recall of dichotically presented consonant--vowel syllables. Stimuli within each dichotic pair were contrasted on the features on voicing and/or place, or were differentiated by manner of production. While listening to the stimuli, the subjects were required to concurrently reduce the(More)
Normal right-handed subjects were presented with luminance patterns varying from sinusoidally in both space and time to the left and right visual fields. With no temporal variation in the stimuli, detection thresholds for the left visual field were lower than those for the right visual field for all spatial frequencies. However, with increasing temporal(More)
The need for NMR selective pulses in magnetic resonance imaging and spectroscopy is reviewed. The shortcomings of the current generation of pulses are discussed and the need for new categories of pulse identified. Strategies for selective pulse design are outlined and two numerical optimization methods, simulated annealing and SPINCALC (a method recently(More)
Recently, we introduced a new numerical approach to the design and optimization of NMR selective pulses, which we have christened "SPINCALC" (J. T. Ngo and P. G. Morris, Biochem. Soc. Trans. 14, 1271 (1986); J. T. Ngo and P. G. Morris, Magn. Reson. Med. 5, 217 (1987]. The first practical application of pulses generated by SPINCALC is demonstrated on a(More)