David E. Ott

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  • Karine Gousset, Sherimay D. Ablan, Lori V. Coren, Akira Ono, Ferri Soheilian, Kunio Nagashima +2 others
  • 2008
HIV-1 particle production is driven by the Gag precursor protein Pr55(Gag). Despite significant progress in defining both the viral and cellular determinants of HIV-1 assembly and release, the trafficking pathway used by Gag to reach its site of assembly in the infected cell remains to be elucidated. The Gag trafficking itinerary in primary monocyte-derived(More)
— We consider the problem of applying aggregate congestion control to a class of distributed multi-media applications known as Cluster-to-Cluster (C-to-C) applications. Flows in such an application share a common intermediary path that is the primary source of network delay and packet loss. Using the Coordination Protocol (CP) architecture, we show how(More)
— In this paper, we identify an emerging and important application class comprised of a set of processes on a cluster of devices communicating to a remote set of processes on another cluster of devices across a common intermediary Internet path. We call these applications cluster-to-cluster applications, or C-to-C applications. The networking requirements(More)
We consider the problem of flow coordination in distributed multimedia applications. Most transport-level protocols are designed to operate independently and lack mechanisms for sharing information with other flows and coordinating data transport in various ways. This limitation becomes problematic in distributed applications that employ numerous flows(More)
BACKGROUND The HIV-1 p6 Gag protein regulates the final abscission step of nascent virions from the cell membrane by the action of two late assembly (L-) domains. Although p6 is located within one of the most polymorphic regions of the HIV-1 gag gene, the 52 amino acid peptide binds at least to two cellular budding factors (Tsg101 and ALIX), is a substrate(More)
  • Eugene V. Barsov, Matthew T. Trivett, Jacob T. Minang, Haosi Sun, Claes Ohlen, David E. Ott
  • 2011
BACKGROUND The SIV/rhesus macaque model for HIV/AIDS is a powerful system for examining the contribution of T cells in the control of AIDS viruses. To better our understanding of CD8(+) T-cell control of SIV replication in CD4(+) T cells, we asked whether TCRs isolated from rhesus macaque CD8(+) T-cell clones that exhibited varying abilities to suppress SIV(More)
  • Lori V Coren, Matthew T Trivett, Sumiti Jain, Victor I Ayala, Gregory Q Del Prete, Claes Ohlen +1 other
  • 2015
The TRIM5α protein is a principal restriction factor that contributes to an HIV-1 replication block in rhesus macaque CD4+ T cells by preventing reverse transcription. HIV-1 restriction is induced in human CD4+ T cells by expression of rhesus TRIM5α as well as those of other old world monkeys. While TRIM5α restriction has been extensively studied in(More)
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