David E. Lanfear

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BACKGROUND Achieving 'personalized medicine' requires enrolling representative cohorts into genetic studies, but patient self-selection may introduce bias. We sought to identify characteristics associated with genetic consent in a myocardial infarction (MI) registry. METHODS We assessed correlates of participation in the genetic sub-study of TRIUMPH, a(More)
INTRODUCTION Inotropes are associated with adverse outcomes in heart failure (HF), raising concern they may accelerate myocardial injury. Whether biomarkers of myocardial necrosis, inflammation and apoptosis change in response to acute milrinone administration is not well established. METHODS Ten patients with severe HF and reduced cardiac output who were(More)
Inhaled short-acting beta-agonist (SABA) medication is commonly used in asthma patients to rapidly reverse airway obstruction and improve acute symptoms. We performed a genome-wide association study of SABA medication response using gene-based association tests. A linear mixed model approach was first used for single-nucleotide polymorphism associations,(More)
I n this issue of the Journal of the American Heart Association, Oemrawsingh et al present a very interesting and well-executed analysis of clinical and pharmacogenetic risk scores for perindopril effectiveness in 8726 patients with stable coronary artery disease. 1 Their results demonstrate that the clinical risk score can predict patient risk but not the(More)
Most current methods for modeling rehospitalization events in heart failure patients make use of only clinical and medications data that is available in the electronic health records. However, information about patient-reported functional limitations, behavioral variables and socio-economic background of patients may also play an important role in(More)
BACKGROUND Accurately identifying heart failure (HF) patients from administrative claims data is useful for both research and quality of care efforts. Yet, there are few comparisons of the various claims data criteria (also known as claims signatures) for identifying HF patients. We compared various HF claim signatures to assess their relative accuracy. (More)
We examined clinical outcomes with proton pump inhibitors (PPI) use within CYP2C19 genotype groups during clopidogrel treatment following acute myocardial infarction (AMI). 2062 patients were genotyped for CYP2C19*2 and *17 variants in TRIUMPH. 12 month clinical outcomes were analyzed among patients discharged on clopidogrel within CYP2C19*2 carrier,(More)
Small datasets pose a tremendous challenge in machine learning due to the few available training examples compounded with the relative rarity of certain labels which can potentially impede the development of a representative hypothesis. We define "Rare Datasets" as ones with low samples/features ratio and a skewed label distribution. Since a generalized(More)
OBJECTIVES Overcoming racial differences in acute coronary syndrome (ACS) outcomes is a strategic goal for U.S. health care. Genetic polymorphisms in the adrenergic pathway seem to explain some outcome differences by race in other cardiovascular diseases treated with β-adrenergic receptor blockade (BB). Whether these genetic variants are associated with(More)
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