David E. Kaplan

Learn More
BACKGROUND Glypican-3 (GPC3) is a heparan-sulfate proteoglycan frequently expressed on the cell membrane of malignant hepatocytes in hepatocellular carcinoma. The capacity for screening potential antibodies in vitro using human hepatocellular lines is critical to ensure binding to this highly post-translationally modified glycophosphatidylinositiol-linked(More)
BACKGROUND Acute hepatitis C (AHCV) provides a diagnostic challenge with diverse clinical presentations. GOALS This study was aimed to examine the clinical and demographic features as well as outcomes in AHCV patients identified from inpatient and outpatient hospital settings. STUDY Patients with suspected AHCV were recruited from Philadelphia VA(More)
BACKGROUND The Child-Turcotte-Pugh (CTP) score is a widely used and validated predictor of long-term survival in cirrhosis. However, the cutpoints for stratifying laboratory variables in CTP have never been validated. OBJECTIVE The objective of this study was to identify evidence-based cutpoints for the CTP laboratory subscores to improve its predictive(More)
A significant proportion of mortality in patients with chronic hepatitis C with or without cirrhosis is related to non-hepatic comorbidities such as cardiovascular or psychiatric disease, drug or alcohol use, renal failure, and non-hepatic cancers [1]. Curing underlying hepatitis C reduces but does not eliminate the higher rates of liver-related and(More)
Peripheral CD27+ memory B-cells become quantitatively reduced and dysfunctional in patients with cirrhosis through poorly characterized mechanisms. We hypothesized that the disappearance of CD27+ memory B-cells results from enhanced sensitivity to apoptosis caused by exposure to gut microbial translocation products. Using isolated naïve and memory B-cells(More)
BACKGROUND To determine the prevalence of patient-reported joint pain among patients with human immunodeficiency virus (HIV)/chronic hepatitis C virus (HCV) coinfection, chronic HCV monoinfection, and HIV monoinfection followed in hepatology and infectious disease outpatient practices. METHODS Standardized interviews were performed among 79(More)
Objectives. This study was performed to define the overall treatment response rates and treatment completion rates among the population of Hepatitis C infected patients at an urban VA Medical Center. Additionally, we examined whether pretreatment liver biopsy is a positive predictor for treatment completion and if the presence of mental health disorders is(More)
  • 1