Learn More
BACKGROUND Since the inception of coronary angioplasty, heparin with or without aspirin has been routinely given intraprocedurally to avoid coronary thrombotic complications. Recently, the direct thrombin inhibitor hirulog has been demonstrated to inactivate clot-bound thrombin. The present study was a multicenter dose escalation of hirulog to determine its(More)
OBJECTIVE To examine the clinical outcome of percutaneous coronary intervention where the procedure was complicated by vessel perforation. SETTING Tertiary referral centre. METHODS The procedural records of 6245 patients undergoing coronary intervention were reviewed. In 52 patients (0.8%) the procedure was complicated by vessel perforation, ranging(More)
A child was recently seen in whom a lower motor neurone facial palsy was one of the presenting signs of malignant hypertension. The association between facial paralysis and hypertension was first noted by Moxon in 1869. Although nearly 100 years have elapsed since then, this clinical picture has received little attention. Under the title: 'Apoplexy into(More)
Over six months 10 patients, representing 20% of those referred to a neurological department with possible idiopathic epilepsy, were subsequently considered to have cardiac arrhythmias that caused or significantly contributed to their symptoms. In some cases relevant arrhythmias were shown only after prolonged electrocardiographic monitoring. Although(More)
The cumulative occlusion rates of aorto-coronary artery venous bypass grafts average from 16 to 26% per distal anastomosis within 12 months and about 2% per following year. The potential benefit of oral anticoagulants and platelet inhibitor drugs has been tested to prevent graft occlusion and to retard the atherosclerotic process. Oral anticoagulants(More)
Platelet size has been shown to reflect platelet activity. We prospectively measured the mean platelet volume (MPV) in 47 patients undergoing single vessel angioplasty for symptomatic angina. The patients underwent repeat angiography 4-8 months later irrespective of symptomatic status. Restenosis was assessed quantitatively by hand held calliper(More)
This study was designed to examine the influence of arteriovenous (A-V) fistulas on cardiac output and left ventricular performance in 13 uremic patients on regular hemodialysis. M-mode echocardiography and systolic time intervals were used to derive indices of left ventricular function, and cardiac output was measured by thermodilution. Measurements were(More)
  • J Hancock, M R Thomas, S Holmberg, R J Wainwright, D E Jewitt
  • 1998
BACKGROUND The value of angioplasty in occluded coronary arteries is limited by a restenosis/reocclusion rate of 50-70%. In patients with subtotal occlusion, stent implantation has been shown to reduce clinical and angiographic restenosis. Retrospective observational studies have suggested that stenting could reduce restenosis in total occlusions. The value(More)