David Cram

Learn More
BACKGROUND Overweight and obesity are common among patients with Cushing's syndrome (CS) and may persist in some patients even after ostensibly curative surgery, contributing to cardiometabolic dysfunction and increased cardiovascular risk. Mifepristone, a selective glucocorticoid receptor antagonist, was effective in controlling hyperglycemia in a 24-week(More)
Through the 1970s, Benjamin Feingold has published a series of studies in which he claimed that a diet free of salicylates, artificial food flavours and colours results in a remission of symptoms in 30 to 50 percent of children diagnosed as hyperactive. Parents of hyperactive children have responded strongly to the hypothesis and have requested that their(More)
In a test of Feingold's hypothesis that food additives trigger the hyperactive response, 26 hyperactive children were randomly assigned to treatment conditions whereby they were given active or placebo medications in combination with challenge cookies with artificial food colors or control cookies without the additives. The children were crossed over into(More)
Six patients with pemphigus vulgaris (PV) who had been treated unsuccessfully with other modalities and who were maintained on prednisone for disease control were started on levamisole in addition to their minimum effective dose of prednisone (40 to 80 mg. daily). All patients responded within 2 to 8 weeks. The minimum effective dose range of prednisone(More)
One hundred patients with a severe relapse of cutaneous psoriasis underwent a full intraoral examination. Nineteen patients had "ectopic geographic tongue" of the palate or buccal mucosa, and there appeared to be an increased incidence of periodontal disease. All other findings were within the normal range. HLA antigen studies of eight patients were carried(More)
Boys with vertebral fractures (VF) identified through routine spine radiographs had milder, less symptomatic, and fewer VF compared to those diagnosed with VF following consultation for back pain. Spontaneous (i.e., medication-unassisted) reshaping of fractured vertebral bodies was absent. Long bone fractures were present even before Duchenne muscular(More)
Patients with erythema multiforme (EM) often have chronic or recurring oral lesions that cause intense pain and interfere with a variety of functions including eating and speech. Previous studies suggest that levamisole restores to normal the function of phagocytes and T lymphocytes, and activates the inflammatory response. In our previous double-blind(More)