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PURPOSE To demonstrate a method of generating patient-specific, biologically-guided radiotherapy dose plans and compare them to the standard-of-care protocol. METHODS AND MATERIALS We integrated a patient-specific biomathematical model of glioma proliferation, invasion and radiotherapy with a multiobjective evolutionary algorithm for intensity-modulated(More)
OBJECT Malignant gliomas are incurable, primary brain neoplasms noted for their potential to extensively invade brain parenchyma. Current methods of clinical imaging do not elucidate the full extent of brain invasion, making it difficult to predict which, if any, patients are likely to benefit from gross total resection. Our goal was to apply a mathematical(More)
In 1972, Serre showed that the adelic Galois representation associated to a non-CM elliptic curve over a number field has open image in GL2(Z). In [Gre10], Greicius develops necessary and sufficient criteria for determining when this representation is actually surjective and exhibits such an example. However, verifying these criteria turns out to be(More)
This article illustrates the use of evidence-based practice to develop conclusions for a forensic report. The authors present a case vignette in which an early adolescent boy was sexually abused by an employee of a private school, and a lawsuit ensued. They explain how to utilize relevant research regarding the prognosis of victims of sexual abuse to(More)
BACKGROUND Thymomas are typically benign tumors of thymic epithelium. Metastases to distal sites, particularly intracranial locations, are extremely rare. Herein, we present the third case of thymoma and the second invasive thymoma to metastasize to the cavernous sinus, adjacent to the pituitary. CASE DESCRIPTION A 41-year-old female patient presented(More)
Fité et al. (2011) describe a generalization of the Sato-Tate conjecture by hypothesizing that the distribution as p varies, for a fixed algebraic curve, of the normalized error terms ((p + 1 − number of solutions)/g √ p) follows the distribution of the trace of a random element of some subgroup of U Sp(2g), called the Sato-Tate group of the curve. In genus(More)
Recently, two phase III studies of bevacizumab, an anti-angiogenic, for newly diagnosed glioblastoma (GBM) patients were released. While they were unable to statistically significantly demonstrate that bevacizumab in combination with other therapies increases the overall survival of GBM patients, there remains a question of potential benefits for(More)
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