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BACKGROUND Preclinical studies in animal models have demonstrated tumor regression following intratumoral administration of an adenovirus vector containing wild-type p53 complementary DNA (Ad-p53). Therefore, in a phase I clinical trial, we administered Ad-p53 to 28 patients with non-small-cell lung cancer (NSCLC) whose cancers had progressed on(More)
IRS Office of Research Headquarters measures and models taxpayer burden, defined as expenditures of time and money by taxpayers to comply with the federal tax system. In this research activity, IRS created two microsimulation models using econometric techniques to enable the Service to produce annual estimates of taxpayer compliance burden for individual(More)
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