David Connor

Sylvie Ramboz3
Dani Brunner3
Seung Kwak2
Liliana Menalled2
3Sylvie Ramboz
3Dani Brunner
2Seung Kwak
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  • Liliana B. Menalled, Andrea E. Kudwa, Sam Miller, Jon Fitzpatrick, Judy Watson-Johnson, Nicole Keating +14 others
  • 2012
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor, cognitive and psychiatric manifestations. Since the mutation responsible for the disease was identified as an unstable expansion of CAG repeats in the gene encoding the huntingtin protein in 1993, numerous mouse models of HD have been generated to study(More)
Huntington's disease (HD) is a progressive neurodegenerative disease marked by psychiatric and motor problems. Recently, these findings have been extended to deficits in sleep and circadian function that can be observed in HD patients and in HD mouse models, with abnormal sleep patterns correlating with symptom severity in patients. Here, we studied the(More)
  • Fuat Balci, Stephen Oakeshott, Jul Lea Shamy, Bassem F. El-Khodor, Igor Filippov, Richard Mushlin +8 others
  • 2013
Phenotyping with traditional behavioral assays constitutes a major bottleneck in the primary screening, characterization, and validation of genetic mouse models of disease, leading to downstream delays in drug discovery efforts. We present a novel and comprehensive one-stop approach to phenotyping, the PhenoCube™. This system simultaneously captures the(More)
Cigarette smoking is common despite adverse health effects. Nicotine's effects on learning may contribute to addiction by enhancing drug-context associations. Effects of nicotine on learning could be direct or could occur by altering systems that modulate cognition. Because thyroid signaling can alter cognition and nicotine/smoking may change thyroid(More)
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