David Christian

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Ewing sarcoma (ES) is an aggressive malignancy driven by an oncogenic fusion protein, EWS-FLI1. Neuropeptide Y (NPY), and two of its receptors, Y1R and Y5R are up-regulated by EWS-FLI1 and abundantly expressed in ES cells. Paradoxically, NPY acting via Y1R and Y5R stimulates ES cell death. Here, we demonstrate that these growth-inhibitory actions of NPY are(More)
How should historians speak truth to power – and why does it matter? Why is five hundred years better than five months or five years as a planning horizon? And why is history – especially long-term history – so essential to understanding the multiple pasts which gave rise to our conflicted present? The History Manifesto is a call to arms to historians and(More)
The formation of carcinogen-DNA adducts within the respiratory epi thelium is thought to be a critical factor in the induction of lung cancer from tobacco smoke. A reliable surrogate measure of carcinogen damage to the lung would be of great value in molecular epidemiological studies of cancer risk. The validity of measurements of DNA adducts formed from(More)
M odern historiography has not fully appreciated the ecological complexity of the Silk Roads. As a result, it has failed to understand their antiquity, or to grasp their full importance in Eurasian history. The role played by the Silk Roads in exchanging goods, technologies , and ideas between regions of agrarian civilization is well understood. Less well(More)
Neuroblastoma (NB) is a pediatric tumor of neural crest origin with heterogeneous phenotypes. Although low-stage tumors carry a favorable prognosis, >50% of high-risk NB relapses after treatment with a fatal outcome. Thus developing therapies targeting refractory NB remains an unsolved clinical problem. Brain-derived neurotrophic factor (BDNF) and its TrkB(More)
A radiation-hard pixel readout chip, FPIX2, is being developed at Fermilab for the recently approved BTeV experiment 11. Although designed for BTeV, this chip should also be appropriate for use by CDF and DZero. A short review of this development eeort is presented. Particular attention is given to the circuit redesign which was made necessary by the(More)
We discuss the physics goals and rationale for a detector to study Beauty and Charm decays in the forward direction at the Fermilab Tevatron. We then describe the BTeV detector which has been designed to achieve these goals and present its physics reach based on extensive simulation. We conclude by comparing BTeV to other experiments designed to explore(More)
Ewing sarcoma (ES) develops in bones or soft tissues of children and adolescents. The presence of bone metastases is one of the most adverse prognostic factors, yet the mechanisms governing their formation remain unclear. As a transcriptional target of EWS-FLI1, the fusion protein driving ES transformation, neuropeptide Y (NPY) is highly expressed and(More)