David Christian

Congyi Lu3
Ewa Izycka-Swieszewska3
Jason U. Tilan3
3Congyi Lu
3Ewa Izycka-Swieszewska
3Jason U. Tilan
3Joanna Kitlinska
3Meredith Horton
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  • Jason U. Tilan, Congyi Lu, Susana Galli, Ewa Izycka-Swieszewska, Joshua Patrick Earnest, Asim Shabbir +13 others
  • 2013
Ewing sarcoma (ES) is an aggressive malignancy driven by an oncogenic fusion protein, EWS-FLI1. Neuropeptide Y (NPY), and two of its receptors, Y1R and Y5R are up-regulated by EWS-FLI1 and abundantly expressed in ES cells. Paradoxically, NPY acting via Y1R and Y5R stimulates ES cell death. Here, we demonstrate that these growth-inhibitory actions of NPY are(More)
  • Magdalena Czarnecka, Emily Trinh, Congyi Lu, Anna Kuan-Celarier, Susana Galli, Sung-Hyeok Hong +11 others
  • 2015
Neuroblastoma (NB) is a pediatric tumor of neural crest origin with heterogeneous phenotypes. Although low-stage tumors carry a favorable prognosis, >50% of high-risk NB relapses after treatment with a fatal outcome. Thus developing therapies targeting refractory NB remains an unsolved clinical problem. Brain-derived neurotrophic factor (BDNF) and its TrkB(More)
M odern historiography has not fully appreciated the ecological complexity of the Silk Roads. As a result, it has failed to understand their antiquity, or to grasp their full importance in Eurasian history. The role played by the Silk Roads in exchanging goods, technologies , and ideas between regions of agrarian civilization is well understood. Less well(More)
  • Sung-Hyeok Hong, Jason U. Tilan, Susana Galli, Ewa Izycka-Swieszewska, Taylor Polk, Meredith Horton +12 others
  • 2015
Ewing sarcoma (ES) develops in bones or soft tissues of children and adolescents. The presence of bone metastases is one of the most adverse prognostic factors, yet the mechanisms governing their formation remain unclear. As a transcriptional target of EWS-FLI1, the fusion protein driving ES transformation, neuropeptide Y (NPY) is highly expressed and(More)
CHRISTIAN, DAVID B. Strategic Deception in Agents. (Under the direction of Assistant Professor R. Michael Young). Despite its negative ethical connotations, deception is a useful tool for human social interaction, and plays an important role in the process of creating the stories that pervade our popular culture. In this paper, we describe the deception(More)
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