Sort by:

• Highly Influential Citations
• Citations
• Acceleration
• Velocity
• Recency

Learn More

Disposition and metabolism of benoxaprofen in laboratory animals and man.

• David Chatfield, J N Green
• Xenobiotica; the fate of foreign compounds in…
• 1978

1. The absorption, distribution, metabolism and excretion of benoxaprofen, a novel anti-inflammatory compound, has been studied in the dog, mouse, rat, rabbit, rhesus monkey and man. 2. Benoxaprofen… (More)

Disposition and metabolism of some nitrofurylthiazoles possessing antiparasitic activity.

• David Chatfield
• Xenobiotica; the fate of foreign compounds in…
• 1976

1. The absorption, distribution and excretion of two 35S-labelled nitrofurylthiazole analogues have been investigated in rats and mice. The compounds are not well absorbed. Higher plasma and tissue… (More)

Determination of isamoxole (N-butyl-N-(4-methyloxazol-2-yl)-2-methylpropanamide, LRCL 3950) in plasma by selected ion monitoring using a stable isotope internal standard.

• David Chatfield, Trevor Woodage
• Biomedical mass spectrometry
• 1978

A selected ion monitoring method for the estimation of an anti-allergy compound isamaxole (N-butyl-N-(4-methyloxazol-2-yl)-2-methylpropanamide, LRCL 3950) in plasma has been developed. The method… (More)

Preliminary studies of absorption and excretion of benoxaprofen in man.

• G. L. Smith, R A Goulbourn, Rebecca Burt, David Chatfield
• British journal of clinical pharmacology
• 1977

1 Benoxaprofen is a new acidic anti-inflammatory compound which was well absorbed after oral administration to man. 2 Single doses of 100, 200 and 400 mg produced mean peak concentrations in the… (More)

Plasma protein binding and interaction studies with benoxaprofen.

• David Chatfield, J N Green, J. C. Kao, Marie Tarrant, Trevor Woodage
• Biochemical pharmacology
• 1978

Pharmacokinetic studies with benoxaprofen in man: prediction of steady-state levels from single-dose data.

• David Chatfield, Marie Tarrant, G. L. Smith, Calandra Speirs
• British journal of clinical pharmacology
• 1977

1 Plasma levels of benoxaprofen were measured in eight subjects 2-168 h after a single oral dose of 100 mg. Pharmacokinetic parameters were estimated by the NON-LIN computer programme using the… (More)

Determination of benoxaprofen [2-(4-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid, LRCL 3794] in biological fluids.

• David Chatfield, Trevor Woodage
• Journal of chromatography
• 1978

Benoxaprofen, a novel anti-inflammatory compound, is efficiently (greater than 95%) extracted from plasma and urine in the pH range 1 to 5 into either chloroform or ether. The compound is determined… (More)

The metabolism of isamoxole in the rat and guinea-pig.

• David Chatfield, J N Green, J. C. Kao, W. C. J. Ross, Trevor Woodage
• Xenobiotica; the fate of foreign compounds in…
• 1979

1. The absorption, metabolism and excretion of isamoxole, (2-methyl-N-butyl-N-(4-methyloxazol-2-yl)propanamide), a compound with anti-allergy properties, has been studied in the rat and guinea-pig.… (More)

The metabolism of acetamidothiazoles in the rat. 2-Acetamido-, 2-acetamido-4-methyl- and 2-acetamido-4-phenyl-thiazole.

• David Chatfield, William H Hunter
• The Biochemical journal
• 1973

The metabolism of some anti-inflammatory acetamidothiazoles was studied in the rat. The main metabolites were the corresponding acetylthiohydantoic acids, produced by fission of the thiazole ring.… (More)

Paramagnetic nuclear magnetic resonance relaxation and molecular mechanics studies of the chloroperoxidase-indole complex: insights into the mechanism of chloroperoxidase-catalyzed regioselective…

• Rui Zhang, Qinghao He, David Chatfield, Xiaotang Wang
• Biochemistry
• 2013

To unravel the mechanism of chloroperoxidase (CPO)-catalyzed regioselective oxidation of indole, we studied the structure of the CPO-indole complex using nuclear magnetic resonance (NMR) relaxation… (More)

• ‹
• 1
• 2
• ›