David Castaño

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BACKGROUND & AIMS Cardiotrophin-1 (CT-1) is a hepatoprotective cytokine that modulates fat and glucose metabolism in muscle and adipose tissue. Here we analyzed the changes in hepatic fat stores induced by recombinant CT-1 (rCT-1) and its therapeutic potential in non-alcoholic fatty liver disease (NAFLD). METHODS rCT-1 was administered to two murine NAFLD(More)
Abbreviations: CT-1, cardiotrophin-1; IL, interleukin; LIF, leukemia inhibitory factor; CNTF, ciliary neurotrophic factor; OSM, oncostatin M; CLC, cardiotrophin like cytokine; NP, neuropoietin; STAT, signal transducer and activator of transcription; EE, energy expenditure; rCT-1, recombinant CT-1; WAT, white adipose tissue; UCP1, uncoupling protein 1; Dio2,(More)
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