David Casero

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BACKGROUND Progress in genome sequencing is proceeding at an exponential pace, and several new algal genomes are becoming available every year. One of the challenges facing the community is the association of protein sequences encoded in the genomes with biological function. While most genome assembly projects generate annotations for predicted protein(More)
Singlet oxygen is a highly toxic and inevitable byproduct of oxygenic photosynthesis. The unicellular green alga Chlamydomonas reinhardtii is capable of acclimating specifically to singlet oxygen stress, but the retrograde signaling pathway from the chloroplast to the nucleus mediating this response is unknown. Here we describe a mutant, singlet oxygen(More)
  • Jorge R. Contreras, Jayanth Kumar Palanichamy, Tiffany M. Tran, Thilini R. Fernando, Norma I. Rodriguez-Malave, Neha Goswami +3 others
  • 2015
miR-146a is a NF-κB induced microRNA that serves as a feedback regulator of this critical pathway. In mice, deficiency of miR-146a results in hematolymphoid cancer at advanced ages as a consequence of constitutive NF-κB activity. In this study, we queried whether the deficiency of miR-146a contributes to B-cell oncogenesis. Combining miR-146a deficiency(More)
  • David Casero, Salemiz Sandoval, Christopher S. Seet, Jessica Scholes, Yuhua Zhu, Vi Luan Ha +3 others
  • 2015
To elucidate the transcriptional landscape that regulates human lymphoid commitment during postnatal life, we used RNA sequencing to assemble the long non-coding transcriptome across human bone marrow and thymic progenitors spanning the earliest stages of B and T lymphoid specification. Over 3000 novel long non-coding RNA genes (lncRNAs) were revealed(More)
  • Beata Berent-Maoz, Encarnacion Montecino-Rodriguez, Michael Fice, David Casero, Christopher S. Seet, Gay M. Crooks +2 others
  • 2015
Cell number in the mouse thymus increases steadily during the first two weeks after birth. It then plateaus and begins to decline by seven weeks after birth. The factors governing these dramatic changes in cell production are not well understood. The data herein correlate levels of High mobility group A 2 protein (Hmga2) expression with these temporal(More)
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