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OBJECTIVES A planned interim analysis of study EGF100151 prompted early termination of enrollment based on a longer time to progression with lapatinib and capecitabine than with capecitabine alone in patients with human epidermal growth factor receptor (HER)-2(+) previously treated advanced breast cancer or metastatic breast cancer (MBC). Here, we report(More)
Real-world speech perception relies on both auditory and visual information that fall within the tolerated range of temporal coherence. Subjects were presented with audiovisual recordings of speech that were offset by either 30 or 300 ms, leading to perceptually coherent or incoherent audiovisual speech, respectively. We provide electroencephalographic(More)
We sought to understand what types of information people use when they infer the attentional states of others. In our study, two groups of participants viewed pictures of social interactions. One group was asked to report where the people in the pictures were directing their attention and how they (the group) knew it. The other group was simply asked to(More)
This paper addresses knowledge-based authentication systems in self-service technology, presenting the design and evaluation of the Visual Identification Protocol (VIP). The basic idea behind it is to use pictures instead of numbers as a means for user authentication. Three different authentication systems based on images and visual memory were designed and(More)
BACKGROUND Incorporation of a taxane as adjuvant treatment for early breast cancer offers potential for further improvement of anthracycline-based treatment. The UK TACT study (CRUK01/001) investigated whether sequential docetaxel after anthracycline chemotherapy would improve patient outcome compared with standard chemotherapy of similar duration. (More)
Patients with simultanagnosia, which is a component of Bálint syndrome, have a restricted spatial window of visual attention and cannot see more than one object at a time. As a result, these patients see the world in a piecemeal fashion, seeing the local components of objects or scenes at the expense of the global picture. To directly test the relationship(More)
Copyright and Moral Rights for the articles on this site are retained by the individual authors and/or other copyright owners. For more information on Open Research Online's data policy on reuse of materials please consult the policies page. Abstract Credible climate predictions require a rational quantification of uncertainty, but full Bayesian calibration(More)
Simultanagnosia is a neuropsychological disorder characterized by a restriction of visuospatial attention. In addition, patients are able to identify local elements of a scene, but not the global whole. This may be due to a failure to scan and assemble local elements into a global whole (i.e. connect-the-dots). We monitored the eye movements of a(More)
The process of cancer invasion involves a complex interplay between cell-cell and cell-medium adhesion, proteolytic enzyme secretion, cell birth and death processes, random and directed motility, and immune response, as well as many other factors. The growth factor TGF beta is known to have a complex effect on this process. It inhibits mitosis and promotes(More)
Machinima is the appropriation of software-generated 3D virtual environments, typically video games, for filmmaking and dramatic productions. The creation and distribution technology of machinima tends to hide the nature of the performer, provoking consideration of a definition of 'liveness' that can accommodate the real-time rendering of screen content by(More)