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Identification of specific PP2A complexes involved in human cell transformation.

• Wen Guo Chen, Richard L. Possemato, Kayleen T Campbell, Courtney A. Plattner, David C. Pallas, William C. Hahn
• Cancer cell
• 2004

The SV40 small t antigen (ST) interacts with the serine-threonine protein phosphatase 2A (PP2A). To investigate the role of this interaction in transformation, we suppressed the expression of the… (More)

Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A

• David C. Pallas, Lilian K. Shahrik, +4 authors Thomas M Roberts
• Cell
• 1990

We have purified the 36 and 63 kd cellular proteins known to associate with polyomavirus middle and small tumor (T) antigens and SV40 small t antigen. Microsequencing of the 36 kd protein indicated… (More)

FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A.

• Usha Narayanan, Vijayalaxmi Nalavadi, +4 authors Stephen T Warren
• The Journal of neuroscience : the official…
• 2007

Fragile X syndrome is a common form of inherited mental retardation and is caused by loss of fragile X mental retardation protein (FMRP), a selective RNA-binding protein that influences the… (More)

WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A.

• Carlos S. Moreno, Sujin Park, +4 authors David C. Pallas
• The Journal of biological chemistry
• 2000

Protein phosphatase 2A (PP2A) is a multifunctional serine/threonine phosphatase that is critical to many cellular processes including development, neuronal signaling, cell cycle regulation, and viral… (More)

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

• William G Kaelin, David C. Pallas, James A. DeCaprio, Frederic J. Kaye, David M. Livingston
• Cell
• 1991

The SV40 T antigen (T)/adenovirus E1A-binding domain of the retinoblastoma gene product (pRB) has been fused to S. japonicum glutathione S-transferase, and the chimera, bound to insoluble… (More)

Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen.

• Kenneth S. Campbell, Egon Ogris, +6 authors David C. Pallas
• Proceedings of the National Academy of Sciences…
• 1994

Polyomavirus middle tumor antigen (MT) transforms a large number of cell types by binding to and modulating the activities of cellular proteins. Previous genetic analysis defined in MT an independent… (More)

A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A.

• Egon Ogris, Xiaobing Du, +4 authors David C. Pallas
• The Journal of biological chemistry
• 1999

Carboxymethylation of proteins is a highly conserved means of regulation in eukaryotic cells. The protein phosphatase 2A (PP2A) catalytic (C) subunit is reversibly methylated at its carboxyl terminus… (More)

Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha.

• Qing Lu, David C. Pallas, Howard K. Surks, W. Baur, Michael E. Mendelsohn, Richard H Karas
• Proceedings of the National Academy of Sciences…
• 2004

Steroid hormone receptors (SHRs) are ligand-activated transcription factors that regulate gene expression. SHRs also mediate rapid, nongenomic cellular activation by steroids. In vascular endothelial… (More)

Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen.

• Xiaoyan Yu, Xianming Du, +6 authors David C. Pallas
• Molecular biology of the cell
• 2001

Binding of different regulatory subunits and methylation of the catalytic (C) subunit carboxy-terminal leucine 309 are two important mechanisms by which protein phosphatase 2A (PP2A) can be… (More)

Protein phosphatase 2A subunit assembly: the catalytic subunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen

• Egon Ogris, Daryl M Gibson, David C. Pallas
• Oncogene
• 1997

The carboxy terminus of protein phosphatase 2A (PP2A) catalytic subunit is highly conserved. Seven out of the last nine residues, including two potential in vivo phosphorylation sites, threonine 304… (More)

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