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- Shitij Kapur, David C. Mamo
- Progress in neuro-psychopharmacology & biological…
- 2003
A review of the history of antipsychotics reveals that while the therapeutic effects of chlorpromazine and reserpine were discovered and actively researched almost concurrently, subsequent drug… (More)
- Pablo M Rusjan, David C. Mamo, Nathalie Ginovart, Douglas F Hussey, Shitij Kapur
- Psychiatry Research: Neuroimaging
- 2006
Manual drawing of regions of interest (ROIs) on brain positron emission tomography (PET) images is labour intensive and subject to intra- and inter-individual variations. To standardize analysis and… (More)
- Hiroyuki Uchida, Hiroyoshi Takeuchi, Ariel Graff-Guerrero, Takefumi Suzuki, Koichiro Watanabe, David C. Mamo
- Journal of clinical psychopharmacology
- 2011
Positron emission tomography (PET) studies proposed a therapeutic window of D2 receptor occupancy (65%-80%) of antipsychotics for the treatment of schizophrenia in young adults. However, this… (More)
- Romina Mizrahi, Pablo M Rusjan, +4 authors Shitij Kapur
- NeuroImage
- 2006
OBJECTIVES
Antipsychotic medications improve psychosis but often induce a state of dysphoria in patients. Blockade of the dopamine D(2) receptors, which is thought to mediate their efficacy, has also… (More)
- Ofer Agid, David C. Mamo, +4 authors Shitij Kapur
- Neuropsychopharmacology
- 2007
Blockade of dopamine D2 receptors remains a common feature of all antipsychotics. It has been hypothesized that the extrastriatal (cortical, thalamic) dopamine D2 receptors may be more critical to… (More)
- Mahesh Menon, Taylor W. Schmitz, +7 authors Shitij Kapur
- Biological Psychiatry
- 2011
BACKGROUND
Referential delusions are the most common symptom of schizophrenia and offer an opportunity to examine the neural correlates of delusions because they occur in discrete episodes that can… (More)
- Romina Mizrahi, Michael Kiang, +4 authors Shitij Kapur
- Schizophrenia Research
- 2006
While most standard symptom scales regard the 'psychotic' or 'positive' dimension of schizophrenia as a single factor, several lines of evidence suggest that psychosis itself is a multidimensional… (More)
- David C. Mamo, Ariel Graff, Romina Mizrahi, Chekkera Shammi, Françoise Romeyer, Shitij Kapur
- The American journal of psychiatry
- 2007
OBJECTIVE
Aripiprazole has a unique pharmacological profile that includes partial agonism at D(2) receptors, antagonism at 5-HT(2) receptors, and partial agonism at 5-HT(1A) receptors. The authors… (More)
- Ariel Graff-Guerrero, Matthaeus Willeit, +7 authors Shitij Kapur
- Human brain mapping
- 2008
The D(2) receptors exist in either the high- or low-affinity state with respect to agonists, and while agonists bind preferentially to the high-affinity state, antagonists do not distinguish between… (More)
- Camilo de la Fuente-Sandoval, Pablo León-OrtÃz, +4 authors Ariel Graff-Guerrero
- Neuropsychopharmacology
- 2011
The glutamatergic and dopaminergic systems are thought to be involved in the pathophysiology of schizophrenia. Their interaction has been widely documented and may have a role in the neurobiological… (More)