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PURPOSE To analyze survival, failure patterns, and toxicity in patients with head-and-neck carcinoma of unknown primary origin (HNCUP) treated with intensity-modulated radiotherapy (IMRT). METHODS AND MATERIALS Records from 27 patients with HNCUP treated during the period 2002-2008 with IMRT were reviewed retrospectively. Nodal staging ranged from N1 to(More)
IMPORTANCE The prognostic significance of p16 in squamous cell carcinoma (SCC) of the hypopharynx (HP) and nasopharynx (NP) and relationship between human papillomavirus (HPV) and p16 is unclear. OBJECTIVES To evaluate the prognostic significance of p16 in pharyngeal subsites (oropharynx [OP], HP, and NP) and assess the relationship between HPV and p16 in(More)
OBJECTIVE To determine the most common indications for revision congenital aural atresia (CAA) surgery and the postoperative healing and hearing outcomes of revision surgery. STUDY DESIGN Retrospective case review. SETTING Tertiary care academic otologic practice. PATIENTS Patients undergoing revision surgery for CAA. INTERVENTION Revision surgery(More)
We evaluated a panel of 8 immunohistochemical biomarkers as predictors of clinical response to definitive intensity-modulated radiotherapy in patients with oropharyngeal squamous cell carcinoma (OPSCC). 106 patients with OPSCC were treated to a total dose of 66-70 Gy and retrospectively analyzed for locoregional control (LRC), disease-free survival (DFS),(More)
OBJECTIVE To determine the predictive ability of the Jahrsdoerfer grading scale score in congenital aural atresia surgery. DESIGN Retrospective review of medical records. SETTING Tertiary referral center. PATIENTS One hundred eight patients with aural atresia. MAIN OUTCOME MEASURES Demographic data, preoperative Jahrsdoerfer score, and postoperative(More)
OBJECTIVE To identify factors that predict complete response of cervical nodal disease to radiation therapy (RT) in patients with oropharyngeal squamous cell carcinoma (OP-SCCA). DESIGN Histologic analysis of prospectively collected specimens and retrospective medical chart review. SETTING Tertiary referral center. SUBJECTS Sixty-nine patients with(More)
OBJECTIVES/HYPOTHESIS Measure compliance with the Accreditation Council of Graduate Medical Education (ACGME) residents' work hour regulations and evaluate their impact on patient care and residents' performance on the Otolaryngology Training Examination (OTE). STUDY DESIGN Retrospective review of an otolaryngology residency program's resident duty hours(More)
IMPORTANCE Rigid esophagoscopy (RE) was once an essential part of the evaluation of patients with head and neck squamous cell carcinoma (HNSCC) due to the high likelihood of identifying a synchronous malignant neoplasm in the esophagus. Given recent advances in imaging and endoscopic techniques and changes in the incidence of esophageal cancer, the current(More)
OBJECTIVE To provide a framework for the management of scalp and skull defects. DESIGN Retrospective chart review. SETTING Two tertiary care hospitals. PATIENTS/INTERVENTION Fifty-six consecutive patients who underwent reconstruction of scalp and/or skull defects with free flaps, rotational skin/fascia flaps, skin grafts, and implants. Defects closed(More)