David C. Shonka

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OBJECTIVE To provide a framework for the management of scalp and skull defects. DESIGN Retrospective chart review. SETTING Two tertiary care hospitals. PATIENTS/INTERVENTION Fifty-six consecutive patients who underwent reconstruction of scalp and/or skull defects with free flaps, rotational skin/fascia flaps, skin grafts, and implants. Defects closed(More)
IMPORTANCE The prognostic significance of p16 in squamous cell carcinoma (SCC) of the hypopharynx (HP) and nasopharynx (NP) and relationship between human papillomavirus (HPV) and p16 is unclear. OBJECTIVES To evaluate the prognostic significance of p16 in pharyngeal subsites (oropharynx [OP], HP, and NP) and assess the relationship between HPV and p16 in(More)
PURPOSE To analyze survival, failure patterns, and toxicity in patients with head-and-neck carcinoma of unknown primary origin (HNCUP) treated with intensity-modulated radiotherapy (IMRT). METHODS AND MATERIALS Records from 27 patients with HNCUP treated during the period 2002-2008 with IMRT were reviewed retrospectively. Nodal staging ranged from N1 to(More)
OBJECTIVE To determine the predictive ability of the Jahrsdoerfer grading scale score in congenital aural atresia surgery. DESIGN Retrospective review of medical records. SETTING Tertiary referral center. PATIENTS One hundred eight patients with aural atresia. MAIN OUTCOME MEASURES Demographic data, preoperative Jahrsdoerfer score, and postoperative(More)
OBJECTIVES Transforming growth factor beta-1 (TGF-beta1) is a known fibrogenic factor with immunosuppressive properties. We wanted to determine the effect of stimulation with TGF-beta1 on nasal polyp-derived fibroblasts and assess the role this molecule would have in polyp formation and growth. STUDY DESIGN Nasal-polyp derived fibroblasts were cultured(More)
We evaluated a panel of 8 immunohistochemical biomarkers as predictors of clinical response to definitive intensity-modulated radiotherapy in patients with oropharyngeal squamous cell carcinoma (OPSCC). 106 patients with OPSCC were treated to a total dose of 66-70 Gy and retrospectively analyzed for locoregional control (LRC), disease-free survival (DFS),(More)
OBJECTIVE To determine the most common indications for revision congenital aural atresia (CAA) surgery and the postoperative healing and hearing outcomes of revision surgery. STUDY DESIGN Retrospective case review. SETTING Tertiary care academic otologic practice. PATIENTS Patients undergoing revision surgery for CAA. INTERVENTION Revision surgery(More)
OBJECTIVE To identify factors that predict complete response of cervical nodal disease to radiation therapy (RT) in patients with oropharyngeal squamous cell carcinoma (OP-SCCA). DESIGN Histologic analysis of prospectively collected specimens and retrospective medical chart review. SETTING Tertiary referral center. SUBJECTS Sixty-nine patients with(More)
OBJECTIVES/HYPOTHESIS Measure compliance with the Accreditation Council of Graduate Medical Education (ACGME) residents' work hour regulations and evaluate their impact on patient care and residents' performance on the Otolaryngology Training Examination (OTE). STUDY DESIGN Retrospective review of an otolaryngology residency program's resident duty hours(More)
When medical management of chronic rhinosinusitis fails to achieve benefit, surgery is often recommended. Functional endoscopic sinus surgery (FESS) has become the method of choice for addressing this disease, and advances in instrumentation to facilitate FESS have led to significant advances and outcome improvements. More recently, balloon dilation of the(More)