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In this letter, a new method is proposed for stability analysis of neural networks (NNs) with a time-varying delay. Some less conservative delay-dependent stability criteria are established by considering the additional useful terms, which were ignored in previous methods, when estimating the upper bound of the derivative of Lyapunov functionals and(More)
This letter is concerned with the stability analysis of neural networks (NNs) with time-varying interval delay. The relationship between the time-varying delay and its lower and upper bounds is taken into account when estimating the upper bound of the derivative of Lyapunov functional. As a result, some improved delay/interval-dependent stability criteria(More)
Sickle-cell disease is one of the most common severe monogenic disorders in the world. Haemoglobin polymerisation, leading to erythrocyte rigidity and vaso-occlusion, is central to the pathophysiology of this disease, although the importance of chronic anaemia, haemolysis, and vasculopathy has been established. Clinical management is basic and few(More)
The molybdenum-containing enzyme sulfite oxidase catalyzes the conversion of sulfite to sulfate, the terminal step in the oxidative degradation of cysteine and methionine. Deficiency of this enzyme in humans usually leads to major neurological abnormalities and early death. The crystal structure of chicken liver sulfite oxidase at 1.9 A resolution reveals(More)
Inosine triphosphate pyrophosphohydrolase (ITPase) deficiency is a common inherited condition characterized by the abnormal accumulation of inosine triphosphate (ITP) in erythrocytes. The genetic basis and pathological consequences of ITPase deficiency are unknown. We have characterized the genomic structure of the ITPA gene, showing that it has eight(More)
The concept of a ‘target-rich, lead-poor’ pipeline in drug discovery, and widespread concern about the attrition rate of chemical compounds in (pre)clinical development, are together fuelling the search for better quality hits and chemical lead series. Researchers are rising to this challenge by devising new ways to identify chemical leads for specific(More)