David C Rees

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Frédéric B Piel, Martin H Steinberg, David C Rees
The New England journal of medicine
2017

Global distribution of the CCR5 gene 32-basepair deletion

Jeremy J. Martinson, Nicola H. Chapman, David C Rees, Yan-Tat Liu, John B. Clegg
Nature Genetics
1997

A mutant allele of the β-chemokine receptor gene CCR5 bearing a 32-basepair (bp) deletion (denoted Δccr5) which prevents cell invasion by the primary transmitting strain of HIV-1 has recently been… (More)

World distribution of factor V Leiden

David C Rees, Monique J. T. Cox, John B. Clegg
The Lancet
1995

We have analysed 3380 chromosomes (1690 unrelated individuals) from twenty-four populations for the presence of factor V Leiden, an important risk factor in venous thromboembolism. The allele… (More)

A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host.

Anton H. Bom, Mark Bradley, +8 authors Ming-qiang Zhang
Angewandte Chemie
2002

Worldwide distribution of a common methylenetetrahydrofolate reductase mutation.

Jerry Schneider, David C Rees, Yan Tat Liu, John B. Clegg
American journal of human genetics
1998

The role of ligand efficiency metrics in drug discovery

Andrew L. Hopkins, György M. Keserü, Paul D. Leeson, David C Rees, Charles H. Reynolds
Nature Reviews Drug Discovery
2014

The judicious application of ligand or binding efficiency metrics, which quantify the molecular properties required to obtain binding affinity for a drug target, is gaining traction in the selection… (More)

FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group.

Faisel Mohammed Abu-Duhier, Anne C Goodeve, +6 authors John T. Reilly
British journal of haematology
2000

Genomic DNA from 106 cases of adult de novo acute myeloid leukaemia (AML) was screened by polymerase chain reaction (PCR) and gel electrophoresis for FLT3 internal tandem duplication (ITD) mutations… (More)

Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency

Satoshi Sumi, Anthony Marin Marinaki, +9 authors J. Duley
Human Genetics
2002

Inosine triphosphate pyrophosphohydrolase (ITPase) deficiency is a common inherited condition characterized by the abnormal accumulation of inosine triphosphate (ITP) in erythrocytes. The genetic… (More)

Structure and function of bacterial photosynthetic reaction centres

George Feher, James P. Allen, Melvin Y Okamura, David C Rees
1989

The primary reaction of photosynthesis is light-driven charge separation, carried out in reaction centres, which are complexes of integral membrane proteins and cofactors. The recent determination of… (More)

Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity.

Steven Howard, Valerio Berdini, +20 authors Paul G Wyatt
Journal of medicinal chemistry
2009

Here, we describe the identification of a clinical candidate via structure-based optimization of a ligand efficient pyrazole-benzimidazole fragment. Aurora kinases play a key role in the regulation… (More)

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