BACKGROUND Human disabled-2 (DAB2), is a multi-function signalling molecule that it is frequently down-regulated in human cancers. We aimed to investigate the possible tumour suppressor effect of DAB2 in nasopharyngeal carcinoma (NPC). METHODS We studied the expression of DAB2 in NPC cell lines, xenografts and primary tumour samples. The status of… (More)
Implantable devices such as cardiac pacemakers, drug-delivery systems, and defibrillators have had a tremendous impact on the quality of live for many disabled people. To date, many devices have been developed for implantation into various parts of the human body. In this paper, we focus on devices implanted in the head. In particular, we describe the… (More)
The functioning of a 16 x 16 pixel pulse frequency modulation (PFM) image sensor for retinal prosthesis is verified through in vitro electrophysiological experiments using detached frog retinas. This image sensor is a prototype for demonstrating the application to in vitro electrophysiological experiments. Each pixel of the image sensor consists of a pulse… (More)
—This paper presents a complete 256-electrode retinal prosthesis chip, which is small and ready for packaging and implantation. It contains 256 separate programmable drivers dedicated to 256 electrodes for flexible stimulation. A 4-wire interface is employed for power and data transmission between the chip and a driving unit. Power and forward data are… (More)
—A CMOS image sensor which is capable to simultaneously sense an optical and an op-chip potential image was designed and fabricated. The sensor was designed with target applications to sense neural activities and DNA spots in on-chip configuration. We designed compatibly configured light sensing pixel and potential sensing pixel. The pixel size is 7.5 µm. A… (More)
This paper describes a retinal prosthetic device using a pulse frequency modulation (PFM) based photosensor with a standard CMOS technology and its modification to stimulate retinal cells effectively. A 32x32-pixel PFM photosensor array chip have been fabricated using 0.6 μm CMOS technology and demonstrated the improved functions.