David C J Carpentier

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Rabies pseudotyped lentiviral vectors have great potential in gene therapy, not least because of their ability to transduce neurons following their distal axonal application. However, very little is known about the molecular processes that underlie their retrograde transport and cell transduction. Using multiple labeling techniques and confocal microscopy,(More)
In a series of studies aimed at investigating the role of environmental surfaces in the transmission of certain respiratory virus infections, it was shown that small amounts of nasal mucus containing rhinovirus (infectious mucus) can spread from fingertips to door knobs, faucet handles, or other environmental surfaces and remain infectious for many hours.(More)
Rabies virus glycoprotein (RVG) can pseudotype lentiviral vectors, although at a lower efficiency to that of vesicular stomatitis virus glycoprotein (VSVG). Transduction with VSVG-pseudotyped vectors of rodent central nervous system (CNS) leads to local neurotropic gene transfer, whereas with RVG-pseudotyped vectors additional disperse transduction of(More)
A formaldehyde-inactivated, alum adsorbed measles virus vaccine prepared from virus propagated on CE tissue cultures was stable for 1 year at 5° C. Vaccine stored under these conditions stimulated an antigenic response in guinea pigs which was not significantly different from that of freshly prepared vaccine. The magnitude of serum-antibody titers was(More)
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