David C. Harrison

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Recently a novel subfamily of closely related orphan G protein-coupled receptors (GPCRs) was identified, called GPRC5A, GPRC5B, GPRC5C and GPRC5D. Based on sequence homology, these receptors were classified as family C GPCRs, which include metabotropic GABA(B) receptors, metabotropic glutamate receptors, the calcium sensing receptor and a number of(More)
Accumulation of amyloid β (Aβ) in brain is a pathological hallmark of Alzheimer's disease (AD). Aβ is generated after sequential cleavage of its parental molecule, amyloid precursor protein (APP), by β- and γ-secretases. Inhibition of γ-secretase activity is an effective approach for the reduction of Aβ levels. Since γ-secretase targets many different(More)
Rarely occurring events present unique challenges to energy constrained systems designed for long term sensing of their occurrence or effect. Unlike periodic sampling or query based sensing systems, longevity cannot be achieved simply by adjusting the sensing nodes’ duty cycle until an equitable balance between data density and network lifetime is(More)
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